Evidence map›Paper›PMID 32451728›Full record

ArticleCellular and molecular neurobiology2021

Short-Term Environmental Enrichment is a Stronger Modulator of Brain Glial Cells and Cervical Lymph Node T Cell Subtypes than Exercise or Combined Exercise and Enrichment.

Gaurav Singhal, Julie Morgan, Frances Corrigan, Catherine Toben, Magdalene C Jawahar, Emily J Jaehne, Jim Manavis, Anthony J Hannan, Bernhard T Baune

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Environmental Enrichment in Stroke Research: an Update.Translational stroke research · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Gaurav SinghalPsychiatric Neuroscience Lab, Discipline of Psychiatry, The University of Adelaide, Adelaide, Australia.ORCID http://orcid.org/0000-0002-9460-0159
Julie MorganPsychiatric Neuroscience Lab, Discipline of Psychiatry, The University of Adelaide, Adelaide, Australia.ORCID http://orcid.org/0000-0001-8245-218X
Frances CorriganDivision of Health Sciences, The University of South Australia, Adelaide, Australia.ORCID http://orcid.org/0000-0001-6150-8893
Catherine TobenPsychiatric Neuroscience Lab, Discipline of Psychiatry, The University of Adelaide, Adelaide, Australia.ORCID http://orcid.org/0000-0001-8399-4108
Magdalene C JawaharPsychiatric Neuroscience Lab, Discipline of Psychiatry, The University of Adelaide, Adelaide, Australia.ORCID http://orcid.org/0000-0001-7136-1848
Emily J JaehnePsychiatric Neuroscience Lab, Discipline of Psychiatry, The University of Adelaide, Adelaide, Australia.ORCID http://orcid.org/0000-0003-0532-1623
Jim ManavisCentre for Neurological Diseases, School of Medicine, Faculty of Health, The University of Adelaide, Adelaide, Australia.ORCID http://orcid.org/0000-0001-7381-7781
Anthony J HannanFlorey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia.ORCID http://orcid.org/0000-0001-7532-8922
Bernhard T BauneFlorey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia. Bernhard.Baune@ukmuenster.de.ORCID http://orcid.org/0000-0001-6548-426X
The University of Adelaide · AUThe University of Melbourne · AULa Trobe University · AUUniversity of South Australia · AU

Funding

National Health and Medical Research Council APP 1043771
6 · The paper itself

Abstract

Physical exercise (PE) and environmental enrichment (EE) can modulate immunity. However, the differential effects of short-term PE, EE, and PE + EE on neuroimmune mechanisms during normal aging has not been elucidated. Hence, a cohort of 3-, 8-, and 13-month-old immunologically unchallenged C57BL/6 wild-type mice were randomly assigned to either Control, PE, EE, or PE + EE groups and provided with either no treatment, a running wheel, a variety of plastic and wooden objects alone or in combination with a running wheel for seven weeks, respectively. Immunohistochemistry and 8-color flow cytometry were used to determine the numbers of dentate gyrus glial cells, and the proportions of CD4

Indexed as

EnvironmentPhysical Conditioning, AnimalAnimalsAntigens, CDAstrocytesBiomarkersBrainCalcium-Binding ProteinsCervical VertebraeDentate GyrusGlial Fibrillary Acidic ProteinImmunophenotypingLymph NodesMiceMice, Inbred C57BLMicrofilament ProteinsAif1 protein, mouseAntigens, CDBiomarkersCalcium-Binding ProteinsGlial Fibrillary Acidic ProteinMicrofilament ProteinsAgingAstrocytesEnvironmental enrichmentMicrogliaPhysical exerciseT cells

Identifiers

PMID32451728
PMCPMC7920895
OpenAlexW3029212761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.