Evidence map›Paper›PMID 32451564›Full record

ArticleHNO2020

[Temporary hyposmia in COVID-19 patients].

S Bocksberger, W Wagner, T Hummel, W Guggemos, M Seilmaier, M Hoelscher, C-M Wendtner

Open access · bronzeAbstract read
In one paragraph

Article in HNO, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

S BocksbergerKlinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, München Klinik Schwabing, Akademisches Lehrkrankenhaus der Ludwig-Maximilians-Universität, Kölner Platz 1, 80804, München, Deutschland.
W WagnerKlinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, München Klinik Schwabing, Akademisches Lehrkrankenhaus der Ludwig-Maximilians-Universität, Kölner Platz 1, 80804, München, Deutschland. wolfgang.wagner@muenchen-klinik.de.
T HummelInterdisziplinäres Zentrum für Riechen und Schmecken, Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Deutschland.
W GuggemosInfektiologie und Tropenmedizin, München Klinik Schwabing, Akademisches Lehrkrankenhaus der Ludwig-Maximilians-Universität, Kölner Platz 1, 80804, München, Deutschland.
M SeilmaierInfektiologie und Tropenmedizin, München Klinik Schwabing, Akademisches Lehrkrankenhaus der Ludwig-Maximilians-Universität, Kölner Platz 1, 80804, München, Deutschland.
M HoelscherAbteilung für Infektions- und Tropenmedizin, Klinikum der Ludwig-Maximilians-Universität, Leopoldstraße 5, 80802, München, Deutschland.
C-M WendtnerInfektiologie und Tropenmedizin, München Klinik Schwabing, Akademisches Lehrkrankenhaus der Ludwig-Maximilians-Universität, Kölner Platz 1, 80804, München, Deutschland.
Ludwig-Maximilians-Universität München · DEMünchen Klinik Schwabing · DETU Dresden · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis is a report on the high incidence of olfactory dysfunction in COVID-19 patients in the first cohort of COVID-19 patients in Germany (Webasto cluster).

methodsLoss of sense of smell and/or taste was reported by 26 of 63 COVID-19 patients (41%), whereas only 31% of the patients experiencing hyposmia had simultaneous symptoms of rhinitis. Smell tests were performed in 14 of these patients and taste tests in 10. The measurements were conducted in a patient care setting in an early COVID-19 cohort.

resultsAn olfactory disorder was present in 10/14 patients, before as well as after nasal decongestion. In 2 of these patients, hyposmia was the leading or only symptom of SARS-CoV‑2 infection. All tested patients reported recovery of smell and/or taste within 8 to 23 days.

conclusionThe data imply that a) COVID-19 can lead to hyposmia in a relevant number of patients, the incidence was approximately 30% in this cohort; b) in most cases, the olfactory disturbance was not associated with nasal obstruction, thus indicating a possible neurogenic origin; and c) the olfactory disorder largely resolved within 1-3 weeks after the onset of COVID-19 symptoms. There were no indications of an increased incidence of dysgeusia. These early data may help in the interpretation of COVID-19-associated hyposmia as well as in the counseling of patients, given the temporary nature of hyposmia observed in this study. Furthermore, according to the current experience, hyposmia without rhinitic obstruction can be the leading or even the only symptom of a SARS-CoV‑2 infection.

Indexed as

Cohort StudiesCoronavirus InfectionsCOVID-19GermanyHumansIncidenceOlfaction DisordersPandemicsPneumonia, ViralAnosmiaCoronavirusDysgeusiaOlfactory disorderSARS-CoV-2

Identifiers

PMID32451564
PMCPMC7246968
OpenAlexW3032836827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.