Evidence map›Paper›PMID 32451489›Full record

ArticleNature structural & molecular biology2020

Allosteric regulation of mammalian Na

Alejandro Llorente-Esteban, Rían W Manville, Andrea Reyna-Neyra, Geoffrey W Abbott, L Mario Amzel, Nancy Carrasco

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Nature structural & molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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  14. Review
  15. The Iodide Transport Defect-Causing Y348D Mutation in the NaThyroid : official journal of the American Thyroid Association · 2021
    Article
  16. Cryo-EM: A new dawn in thyroid biology.Molecular and cellular endocrinology · 2021
    Review
  17. Article
  18. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Alejandro Llorente-EstebanDepartment of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
Rían W ManvilleBioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.
Andrea Reyna-NeyraDepartment of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
Geoffrey W AbbottBioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.
L Mario AmzelDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA. mamzel@jhmi.edu.
Nancy CarrascoDepartment of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA. nancy.carrasco@vanderbilt.edu.ORCID http://orcid.org/0000-0001-8586-6249
Vanderbilt University · USUniversity of California, Irvine · USJohns Hopkins University · US

Funding

THYROID SODIUM I/ SYMPORTERR01DK041544 · NIDDK · YESHIVA UNIVERSITY · PI ABBOTT, GEOFFREY W, CARRASCO, NANCY · 1989 to 2017
$5.6M
Mechanism of I- transport by the Na+/l- symporter (NIS)R01GM114250 · NIGMS · YALE UNIVERSITY · PI Nancy Carrasco · 2016 to 2026
$4.8M
NIDDK NIH HHS R01 DK041544NIGMS NIH HHS R01 GM114250
6 · The paper itself

Abstract

The Na

Indexed as

Allosteric RegulationAllosteric SiteAnimalsAnionsBinding SitesBiological TransportDogsElectrophysiologyFemaleHumansIodineMadin Darby Canine Kidney CellsMutationOocytesPerchloratesRatsAnionsIodineperchloratePerchloratesSodiumSodium-Iodide SymportersSymporters

Identifiers

PMID32451489
PMCPMC10158964
OpenAlexW3028304065

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.