ArticleNature methods2020
Intelligent image-based deformation-assisted cell sorting with molecular specificity.
Article in Nature methods, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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The trial behind it
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Who cites it
53 citing papers in PubMed.
- Real-Time Biophysical Phenotyping and Sorting of Transiting Cells Along a Constriction Microchannel.Micromachines · 2026Article
- Mechanistic insights into cellular deformation enable enhanced extensional-flow cytometry for label-free classification and sorting.Microsystems & nanoengineering · 2026Article
- Automation and improvement of WBC mechanical profiling in deformability cytometry.Biophysical journal · 2026Article
- Intelligent label-free droplet microfluidic sorting system for single-cell encapsulation and morphology-guided screening.Microsystems & nanoengineering · 2026Article
- Microfluidic technologies for enhancing the potency, predictability and affordability of adoptive cell therapies.Nature biomedical engineering · 2025Review
- Longitudinal associations between depressive symptoms and cell deformability: do glucocorticoids play a role?European archives of psychiatry and clinical neuroscience · 2025Article
- Cell trajectory modulation: rapid microfluidic biophysical profiling of CAR T cell functional phenotypes.Nature communications · 2025Article
- MIML: multiplex image machine learning for high precision cell classification via mechanical traits within microfluidic systems.Microsystems & nanoengineering · 2025Article
- Mechanical phenotype of cancer cells and its measurement methodology.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Article
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- Deep Learning-Assisted Label-Free Parallel Cell Sorting with Digital Microfluidics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Droplet-based bioprinting.Nature reviews. Methods primers · 2025Article
- Real-time viscoelastic deformability cytometry: High-throughput mechanical phenotyping of liquid and solid biopsies.Science advances · 2024Article
- Biophysical assays to test cellular mechanosensing: moving towards high throughput.Biophysical reviews · 2024Review
- Information-Distilled Generative Label-Free Morphological Profiling Encodes Cellular Heterogeneity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Harnessing the power of Microscale AcoustoFluidics: A perspective based on BAW cancer diagnostics.Biomicrofluidics · 2024Article
- Classification of fetal and adult red blood cells based on hydrodynamic deformation and deep video recognition.Biomedical microdevices · 2023Article
- Rapid deformability cytometry for tissue biopsies.Nature biomedical engineering · 2023Article
- Rapid single-cell physical phenotyping of mechanically dissociated tissue biopsies.Nature biomedical engineering · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although label-free cell sorting is desirable for providing pristine cells for further analysis or use, current approaches lack molecular specificity and speed. Here, we combine real-time fluorescence and deformability cytometry with sorting based on standing surface acoustic waves and transfer molecular specificity to image-based sorting using an efficient deep neural network. In addition to general performance, we demonstrate the utility of this method by sorting neutrophils from whole blood without labels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.