Evidence map›Paper›PMID 32451472›Full record

ArticleNature microbiology2020

Prokaryotic single-cell RNA sequencing by in situ combinatorial indexing.

Sydney B Blattman, Wenyan Jiang, Panos Oikonomou, Saeed Tavazoie

Open access · greenAbstract read
In one paragraph

Article in Nature microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed
8.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 213 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Fast, StreamlinedChemical & biomedical imaging · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Uniform pre-processing of bacterial single-cell RNA-seq.bioRxiv : the preprint server for biology · 2026
    Article
  20. Review

78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sydney B Blattman *Department of Biological Sciences, Columbia University, New York City, NY, USA.
Wenyan Jiang *Department of Biological Sciences, Columbia University, New York City, NY, USA.
Panos OikonomouDepartment of Biological Sciences, Columbia University, New York City, NY, USA.ORCID http://orcid.org/0000-0001-7387-0312
Saeed TavazoieDepartment of Biological Sciences, Columbia University, New York City, NY, USA. st2744@columbia.edu.ORCID http://orcid.org/0000-0003-2183-4162
Columbia University · US

Funding

Systems biological interrogation of bacterial persistenceR01AI077562 · NIAID · PRINCETON UNIVERSITY · PI TAVAZOIE, SAEED F · 2010 to 2024
$6.4M
NIAID NIH HHS R01 AI077562
6 · The paper itself

Abstract

Despite longstanding appreciation of gene expression heterogeneity in isogenic bacterial populations, affordable and scalable technologies for studying single bacterial cells have been limited. Although single-cell RNA sequencing (scRNA-seq) has revolutionized studies of transcriptional heterogeneity in diverse eukaryotic systems

Indexed as

Prokaryotic CellsSequence Analysis, RNASingle-Cell AnalysisComputational BiologyGene Expression ProfilingHigh-Throughput Nucleotide SequencingRNATranscriptomeRNA

Identifiers

PMID32451472
PMCPMC8330242
OpenAlexW3028351109

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.