ArticleDental materials : official publication of the Academy of Dental Materials2020
Bioactive amorphous magnesium phosphate-polyetheretherketone composite filaments for 3D printing.
Article in Dental materials : official publication of the Academy of Dental Materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 66 citations in OpenAlex.
- Biodegradable and osteoconductive sodium alginate-gelatin/amorphous magnesium phosphate 3D-printed scaffolds for craniofacial bone regeneration.Journal of the mechanical behavior of biomedical materials · 2026Article
- Bilayer gelatin-methacryloyl scaffold for pulp inflammation suppression and dentin-like tissue regeneration.Journal of controlled release : official journal of the Controlled Release Society · 2026Article
- Influence of fused deposition modeling parameters on the mechanical and thermal properties of 3D-printed PEEK dental endosseous implants.Dental materials : official publication of the Academy of Dental Materials · 2026Article
- 3D Printing β-TCP-laden GelMA/Alginate Interpenetrating-Polymer-Network Biomaterial Inks for Bone Tissue Engineering.Bioprinting (Amsterdam, Netherlands) · 2025Article
- Osseointegration of 3D-Printable Polyetheretherketone-Magnesium Phosphate Bioactive Composites for Craniofacial and Orthopedic Implants.ACS biomaterials science & engineering · 2025Article
- Polyetheretherketone bioactivity induced by farringtonite.Scientific reports · 2024Article
- Novel 3D printable PEEK-HA-MgEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Article
- Mechanical performance and bioactivation of 3D-printed PEEK for high-performance implant manufacture: a review.Progress in biomaterials · 2023Review
- A biomimetic gradient porous cage with a micro-structure for enhancing mechanical properties and accelerating osseointegration in spinal fusion.Bioactive materials · 2023Article
- Magnesium surface-activated 3D printed porous PEEK scaffolds forBioactive materials · 2023Article
- Review
- 3D printing biocompatible materials with Multi Jet Fusion for bioreactor applications.International journal of bioprinting · 2023Article
- Research progress of 3D printed poly (ether ether ketone) in the reconstruction of craniomaxillofacial bone defects.Frontiers in bioengineering and biotechnology · 2023Review
- Strategies to improve bioactive and antibacterial properties of polyetheretherketone (PEEK) for use as orthopedic implants.Materials today. Bio · 2022Review
- 3D-Printed Piezoelectric Porous Bioactive Scaffolds and Clinical Ultrasonic Stimulation Can Help in Enhanced Bone Regeneration.Bioengineering (Basel, Switzerland) · 2022Article
- Review
- 3D Printed Strontium and Zinc Doped Hydroxyapatite Loaded PEEK for Craniomaxillofacial Implants.Polymers · 2022Article
- 3D printing of bone and cartilage with polymer materials.Frontiers in pharmacology · 2022Review
- Injectable Multifunctional Drug Delivery System for Hard Tissue Regeneration under Inflammatory Microenvironments.ACS applied bio materials · 2021Article
- Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveThe aim of this study was to develop bioactive and osseointegrable polyetheretherketone (PEEK)-based composite filaments melt-blended with novel amorphous magnesium phosphate (AMP) particles for 3D printing of dental and orthopedic implants. MATERIALS AND
methodsA series of materials and biological analyses of AMP-PEEK were performed. Thermal stability, thermogravimetric and differential scanning calorimetry curves of as-synthesized AMP were measured. Complex viscosity, elastic modulus and viscous modulus were determined using a rotational rheometer. In vitro bioactivity was analyzed using SBF immersion method. SEM, EDS and XRD were used to study the apatite-forming ability of the AMP-PEEK filaments. Mouse pre-osteoblasts (MC3T3-E1) were cultured and analyzed for cell viability, proliferation and gene expression. For in vivo analyses, bare PEEK was used as the control and 15AMP-PEEK was chosen based on its in vitro cell-related results. After 4 or 12 weeks, animals were euthanized, and the femurs were collected for micro-computed tomography (μ-CT) and histology.
resultsThe collected findings confirmed the homogeneous dispersion of AMP particles within the PEEK matrix with no phase degradation. Rheological studies demonstrated that AMP-PEEK composites are good candidates for 3D printing by exhibiting high zero-shear and low infinite-shear viscosities. In vitro results revealed enhanced bioactivity and superior pre-osteoblast cell function in the case of AMP-PEEK composites as compared to bare PEEK. In vivo analyses further corroborated the enhanced osseointegration capacity for AMP-PEEK implants. SIGNIFICANCE: Collectively, the present investigation demonstrated that AMP-PEEK composite filaments can serve as feedstock for 3D printing of orthopedic and dental implants due to enhanced bioactivity and osseointegration capacity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.