ReviewInternational review of neurobiology2020
The influence of stress and early life adversity on addiction: Psychobiological mechanisms of risk and resilience.
Review in International review of neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Patterns of adaptation to stress cardiovascular responses in smokers during ad libitum smoking and withdrawal.Psychophysiology · 2025Trial
- The Orexin System Modulates Stress-Induced Alcohol Preference and Reinstatement in Adolescents: Bioinformatics and Experimental Evidence.Addiction biology · 2026Article
- Childhood trauma and impulsive behaviors: the multiple chain mediating effects of neuroticism, stress perception and depression.BMC psychology · 2026Article
- Low self esteem contributes to medical student social media addiction through chain mediation by academic Involution and anxiety.Scientific reports · 2025Article
- Stress across systems and lifespan: emerging biomarkers and mechanisms of resilience.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Early life adversity increases risk for chronic post-traumatic pain, data from humans and rodents.Pain · 2025Article
- A cohort-based assessment of drug use trends during the COVID-19 pandemic: relationship with mood and sociodemographic factors in Brazil.Frontiers in psychiatry · 2025Article
- Opioid drug seeking after early-life adversity: a role for delta opioid receptors.Addiction neuroscience · 2024Article
- A Preliminary Investigation of a Conceptual Model Describing the Associations Between Childhood Maltreatment and Alcohol Use Problems.Brain sciences · 2024Article
- Associations Between Childhood Trauma and Tobacco Use Outcomes in Adults after Overnight Abstinence.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- Early life stress and body-mass-index modulate brain connectivity in alcohol use disorder.Translational psychiatry · 2024Article
- Proposing an integrative, dynamic and transdiagnostic model for addictions: dysregulation phenomena of the three main modes of the predostatic mind.Frontiers in psychiatry · 2023Article
- Enduring disruption of reward and stress circuit activities by early-life adversity in male rats.Translational psychiatry · 2022Article
- Limitations of the protective measure theory in explaining the role of childhood sexual abuse in eating disorders, addictions, and obesity: an updated model with emphasis on biological embedding.Eating and weight disorders : EWD · 2022Review
- Effects of regular cannabis and nicotine use on acute stress responses: chronic nicotine, but not cannabis use, is associated with blunted adrenocortical and cardiovascular responses to stress.Psychopharmacology · 2022Article
- Resilience to the effects of social stress on vulnerability to developing drug addiction.World journal of psychiatry · 2022Review
- Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications.Nutrients · 2020Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Preclinical, clinical, and population research demonstrates that stress and early life adversity (ELA) increase vulnerability to initiate, maintain, and relapse in addiction. Individuals with addiction problems have higher prevalence of trauma exposure than nondrug users; and this association extends to young populations (e.g., adolescents). Mechanisms for these associations likely involve multiple systems, including changes in the mesolimbic reward functions, HPA axis stress response, and other stress- and reward-related pathways. Other brain morphological and functional changes are also likely involved and directly contribute to the neurohormonal and behavioral alterations observed during adulthood in those exposed to ELA. Stress-related risk is influenced by sex, genetic factors, and resilience, among other factors. Our heuristic model proposes that long-term effects of stress and ELA on the brain contribute to dysregulation of the stress response, emotional reactivity, reward systems, cognitive dysregulation, and delay discounting that lead to impulsive and high-risk behaviors, such as drug use and relapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.