Evidence map›Paper›PMID 32450833›Full record

ArticleBMC ophthalmology2020

Anterior segment optical coherence tomography imaging in peripheral ulcerative keratitis, a corneal structural description.

Clemence Bonnet, Louis Debillon, Saba Al-Hashimi, Florence Hoogewoud, Dominique Monnet, Jean-Louis Bourges, Antoine Brézin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Role of AS-OCT in Managing Corneal Disorders.Diagnostics (Basel, Switzerland) · 2022
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Clemence BonnetOphthalmology Department, Cochin Hospital, Paris University, Paris, France. clemence.p.bonnet@gmail.com.ORCID http://orcid.org/0000-0003-1732-7643
Louis DebillonOphthalmology Department, Cochin Hospital, Paris University, Paris, France.
Saba Al-HashimiStein Eye Institute, David Geffen School of Medicine, University of California in Los Angeles, 100 Stein Plaza, Los Angeles, CA, 90095, USA.
Florence HoogewoudOphthalmology Department, Cochin Hospital, Paris University, Paris, France.
Dominique MonnetOphthalmology Department, Cochin Hospital, Paris University, Paris, France.
Jean-Louis BourgesOphthalmology Department, Cochin Hospital, Paris University, Paris, France.
Antoine BrézinOphthalmology Department, Cochin Hospital, Paris University, Paris, France.
Hôpital Cochin · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnterior segment optical coherence tomography (AS OCT) is a helpful tool used to diagnose and manage many corneal conditions, but its use has not been reported in case of peripheral ulcerative keratitis (PUK). The aim of this study is to describe AS OCT findings in cases of PUK.

methodsRetrospective observational case series of six eyes presenting with a PUK and proven systemic vasculitis. Clinical course, slit lamp photographs, and AS OCT findings were the main outcomes.

resultsThe AS OCT findings were found to correlate with the ocular disease's level of activity. In the acute stage, an absence of corneal epithelium, a scrambled appearance of the anterior stroma and a heterogeneous stromal reflectivity were observed. During the reduction of disease level activity, an irregular hyporeflective epithelium, a smoother anterior stroma, and a homogenous hyperreflective stroma were seen. At the healed stage, a filling of the corneal defect by a hyporeflective thick epithelium, the persistence of the hyperreflective underlying stroma, and a demarcation line were observed. The mean total corneal thickness at last follow-up was significantly thicker (509 ± 147 μm) compared with the mean corneal thickness at onset (408 ± 131 μm; P = 0.03).

conclusionsAS OCT provides an assessment of structural changes occurring in PUK, useful for its diagnosis and monitoring.

Indexed as

Tomography, Optical CoherenceAdultAgedAnterior Eye SegmentAnti-Bacterial AgentsAzithromycinCorneal StromaCorneal UlcerDrug Therapy, CombinationEpithelium, CornealFemaleFollow-Up StudiesGlucocorticoidsHumansImmunosuppressive AgentsMaleAnti-Bacterial AgentsAzithromycinGlucocorticoidsImmunosuppressive AgentsMethylprednisoloneAnterior segment optical coherence tomographyCorneaPeripheral ulcerative keratitisSystemic vasculitis

Identifiers

PMID32450833
PMCPMC7249626
OpenAlexW3030527872

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.