ArticleBMC neurology2020
The burden and outcomes of stroke in young adults at a tertiary hospital in Tanzania: a comparison with older adults.
Article in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Trends and Clinical Characteristics of HIV and Cerebrovascular Disease in Low- and Middle-Income Countries (LMICs) Between 1990 and 2021.Current HIV/AIDS reports · 2022Pooled it
- Stroke Prevention with Hydroxyurea Enabled through Research and Education: A Phase 2 Primary Stroke Prevention Trial in Sub-Saharan Africa.Acta haematologica · 2023Trial
- Clinical characteristics and frequent risk factors in young adult patients with stroke at a tertiary care hospital in Honduras.Frontiers in stroke · 2026Article
- Stroke in Young Adults: An Overview and Non-Pharmacological Preventive Strategies.Brain sciences · 2025Review
- The burden of hyponatremia and 30-day outcomes among adults admitted with stroke at a large tertiary teaching hospital in Northwestern Tanzania.Frontiers in stroke · 2025Article
- Implementing Acute Stroke Services in Sub-Saharan Africa: Steps, Progress, and Perspectives from the Tanzania Stroke Project.Cerebrovascular diseases extra · 2025Article
- Impact of diabetes mellitus on 30-day mortality among acute stroke patients in northern Tanzania.PloS one · 2025Article
- Intensive vital signs monitoring reduces 30-day mortality among stroke patients: A cohort study from Tanzania.PloS one · 2025Article
- Stroke characteristics and outcomes in urban Tanzania: Data from the Prospective Lake Zone Stroke Registry.International journal of stroke : official journal of the International Stroke Society · 2024Article
- Predictors of 30-day mortality following the first episode of stroke among patients admitted at referral hospitals in Dodoma, central Tanzania: A prospective longitudinal observational study.Health science reports · 2024Article
- 30-day in-hospital stroke case fatality and significant risk factors in sub-Saharan-Africa: A systematic review and meta-analysis.PLOS global public health · 2024Article
- Incidence of mortality and risk factors among adult stroke patients in public hospitals Jigjiga town Somali region, Ethiopia: Cohort study design.SAGE open medicine · 2024Article
- A Spatial Variation Analysis of In-Hospital Stroke Mortality Based on Integrated Pre-Hospital and Hospital Data in Mashhad, Iran.Archives of Iranian medicine · 2023Article
- Thirty-day mortality rates among young adult stroke patients and their characteristics at Kiruddu and Mulago hospitals in Uganda: A prospective observational cohort study.PLOS global public health · 2023Article
- Predictors of 30-day mortality among patients with stroke admitted at a tertiary teaching hospital in Northwestern Tanzania: A prospective cohort study.Frontiers in neurology · 2022Article
- Incidence and characteristics of stroke in Zanzibar-a hospital-based prospective study in a low-income island population.Frontiers in neurology · 2022Article
- Developing a Sustainable Cardiovascular Disease Research Strategy in Tanzania Through Training: Leveraging From the East African Centre of Excellence in Cardiovascular Sciences Project.Frontiers in cardiovascular medicine · 2022Review
- The burden, correlates and outcomes of left ventricular hypertrophy among young Africans with first ever stroke in Tanzania.BMC cardiovascular disorders · 2021Article
- The Survival Status and Predictors of Mortality Among Stroke Patients at North West Ethiopia.Risk management and healthcare policy · 2021Article
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Abstract
backgroundStroke burden in young adults is growing associated with unique risk factors and devastating outcomes. We aimed to investigate the magnitude, risk factors and outcomes of first ever stroke in young adults ≤45 years compared to older adults > 45 years.
methodsAll patients with a World Health Organization clinical definition of stroke at a tertiary hospital in Tanzania were enrolled. The National Institute of Health Stroke Scale and Modified Rankin Scale were used to assess admission stroke severity and outcomes respectively. Kaplan-Meier analysis was used to describe survival and Cox-proportional hazards model was used to examine predictors of fatality.
resultsWe enrolled 369 first ever stroke participants over 8 months. First strokes accounted for one quarter of the medical admissions in both younger and older groups, 123/484 {(25.4%) [95% CI 21.5-29.3%]} and 246/919 {(26.8%) [95% CI 23.9-29.6%]} respectively. Hemorrhagic stroke occurred in 47 (42.3%) vs 62 (27.2%) for the young and old respectively p = 0.005. Factors associated with stroke in the young were: a new diagnosis of hypertension in 33 (26.8%) vs 23 (9.3%) p < 0.001, HIV infection 12 (9.8%) vs 7 (2.8%) p = 0.005, use of hormonal contraception in females 33 (48.5%) vs 13 (9.4%) p < 0.001, elevated serum low density lipoproteins 28 (27.7%) vs 29 (16.4%) p = 0.024, hypercholesteremia 34 (31.2%) vs 40 (20.2%), p = 0.031, sickle cell disease 11 (9.7%) vs 9 (4.2%) p = 0.047 and thrombocytosis 12 (16.9%) vs 8 (5.6%) p = 0.007. The overall 30-day fatality rate was 215 (61.3%); 57 (49.1%) vs 158 (67.2%) in the young and old respectively. Independent predictors of fatality were: severe stroke {HR 10.35 (95% CI: 1.397-76.613)}, leukocytosis {HR 2.23 (95% CI: 1.448-3.419)} and fever {HR 1.79 (95% CI: 1.150-2.776)}.
conclusionsThere is a high burden of stroke in young adults that is coupled with a high 30-day fatality rate. Screening and management of hypertension is crucial in the prevention of stroke. More research is needed to identify factors which cause death, allowing the development of sustainable interventions to reduce early post stroke fatality in this group.
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