Evidence map›Paper›PMID 32450611›Full record

ArticleJournal of cellular and molecular medicine2020

Classic and targeted anti-leukaemic agents interfere with the cholesterol biogenesis metagene in acute myeloid leukaemia: Therapeutic implications.

Fangli Chen, Xue Wu, Cristina Niculite, Marilena Gilca, Daniela Petrusca, Adriana Rogozea, Susan Rice, Bin Guo, Shawn Griffin, George A Calin and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Frontiers in microbiology · 2022
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Fangli ChenMelvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA.
Xue WuMelvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA.ORCID 0000-0002-0511-9436
Cristina NiculiteMelvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA.
Marilena GilcaMelvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA.
Daniela PetruscaMelvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA.
Adriana RogozeaMelvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA.
Susan RiceMelvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA.
Bin GuoMelvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA.
Shawn GriffinMelvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA.
George A CalinDivision of Cancer Medicine, Department of Experimental Therapeutics, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-7427-0578
H Scott BoswellMelvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA.
Heiko KonigMelvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA.ORCID 0000-0002-6871-7388
Indiana University Health · USThe University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3M
Project-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7M
Novel extra cellular RNA-based combinatorial RNA inhibition therapyUH3TR000943 · NCATS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CALIN, GEORGE A., LOPEZ-BERESTEIN, GABRIEL · 2015 to 2017
$3.2M
Protein-coding and non-coding RNA biomarkers for early detection of CLLR01CA182905 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ABRUZZO, LYNNE V., CALIN, GEORGE A. · 2014 to 2018
$2.9M
miR-155 targeted therapeutics for precision medicine in lung cancerR01CA222007 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CALIN, GEORGE A., CRISTINI, VITTORIO · 2018 to 2022
$2.6M
NCATS NIH HHS UH3 TR000943NCI NIH HHS 1R01CA182905-01NCI NIH HHS 1R01CA222007-01A1NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA082709NCI NIH HHS R01 CA182905NCI NIH HHS R01 CA222007NIDDK NIH HHS U54 DK106846NIH HHS 1S10D012270NIH HHS UH3TR00943-01
6 · The paper itself

Abstract

Despite significant advances in deciphering the molecular landscape of acute myeloid leukaemia (AML), therapeutic outcomes of this haematological malignancy have only modestly improved over the past decades. Drug resistance and disease recurrence almost invariably occur, highlighting the need for a deeper understanding of these processes. While low O

Indexed as

AdultAgedAged, 80 and overApoptosisBenzothiazolesBiosynthetic PathwaysCell Line, TumorCell ProliferationCholesterolCytarabineDown-RegulationFemaleGene Expression Regulation, LeukemicHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIntracellular SpaceBenzothiazolesCholesterolCytarabineHydroxymethylglutaryl-CoA Reductase InhibitorsPhenylurea CompoundsquizartinibRosuvastatin Calciumacute myeloid leukaemiacholesterolhypoxiastatins

Identifiers

PMID32450611
PMCPMC7339218
OpenAlexW3031413714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.