ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2021
The vagus nerve mediates the suppressing effects of peripherally administered oxytocin on methamphetamine self-administration and seeking in rats.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review.Pharmacological reviews · 2022Pooled it
- A positive affect intervention alters leukocyte DNA methylation in sexual minority men with HIV who use methamphetamine.Brain, behavior, and immunity · 2024Trial
- Differences between males and females in psychostimulant/sucrose self-administration (when observed) may not necessarily be driven by biological sex.bioRxiv : the preprint server for biology · 2026Article
- The oxytocin system mediates behavioral and neurobiological alterations associated with early adversity.Molecular psychiatry · 2026Article
- Vagal Oxytocin Receptors as Molecular Targets in Gut-Brain Signaling: Implications for Appetite, Satiety, Obesity, and Esophageal Motility-A Narrative Review.International journal of molecular sciences · 2025Review
- Article
- How does oxytocin modulate human behavior?Molecular psychiatry · 2025Review
- Emerging medications and pharmacological treatment approaches for substance use disorders.Pharmacology, biochemistry, and behavior · 2025Review
- Grandmotherhood is associated with reduced OXTR DNA methylation.Psychoneuroendocrinology · 2024Article
- Article
- Peripherally restricted oxytocin is sufficient to reduce food intake and motivation, while CNS entry is required for locomotor and taste avoidance effects.Diabetes, obesity & metabolism · 2023Article
- The Role of Oxytocin and Vasopressin in Drug-Induced Reward-Implications for Social and Non-Social Factors.Biomolecules · 2023Review
- Oxytocin receptors are widely distributed in the prairie vole (Microtus ochrogaster) brain: Relation to social behavior, genetic polymorphisms, and the dopamine system.The Journal of comparative neurology · 2022Article
- Oxytocin as an adolescent treatment for methamphetamine addiction after early life stress in male and female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Oxytocin and vasopressin: Signalling, behavioural modulation and potential therapeutic effects.British journal of pharmacology · 2022Review
- Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse.Neuron · 2022Article
- Effects of Intranasal Administration of Oxytocin and Vasopressin on Social Cognition and Potential Routes and Mechanisms of Action.Pharmaceutics · 2022Review
- Consequences of pandemic-associated social restrictions: Role of social support and the oxytocin system.Psychoneuroendocrinology · 2022Review
- Chloral Hydrate Alters Brain Activation Induced by Methamphetamine-Associated Cue and Prevents Relapse.Frontiers in molecular neuroscience · 2022Article
- Factors modulating the incubation of drug and non-drug craving and their clinical implications.Neuroscience and biobehavioral reviews · 2021Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neuropeptide oxytocin has emerged as a promising pharmacotherapy for methamphetamine (METH) addiction, and clinical trials of intranasal oxytocin are underway. However, there is debate as to how peripherally administered oxytocin alters brain signalling to modulate addiction processes. Interestingly, there is evidence for functional interactions between peripheral oxytocin administration and the vagus nerve. Therefore, this study investigated whether the effects of peripherally administered oxytocin require vagal signalling to reduce METH self-administration and reinstatement of METH-seeking behaviours. Male and female Sprague-Dawley rats underwent surgery for jugular catheterisation and either subdiaphragmatic vagotomy (SDV) or a sham operation. Rats were trained to self-administer METH, and the effect of peripherally administered oxytocin on METH intake was assessed. Rats then underwent extinction, and effects of oxytocin were assessed on cue- and METH-induced reinstatement of METH-seeking. Oxytocin treatment robustly attenuated METH intake in both sexes, and SDV entirely prevented the suppressant effect of oxytocin (0.3 mg/kg) on METH intake, and partially prevented the effects of 1 mg/kg oxytocin in both sexes. After extinction, SDV decreased the suppressing effects of oxytocin on cue- and METH-primed reinstatement in males, but not females. SDV was functionally confirmed by measuring food intake following administration of the vagal dependent peptide, cholecyostokin-8. Our data suggest that vagus nerve signalling is required for the inhibitory effects of peripherally administered oxytocin on METH self-administration and reinstatement, and that this vagal dependency is partially mediated by sex and drug withdrawal. This study has implications for the use of oxytocin as a therapy for METH use disorder for both sexes.
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