ArticleiScience2020
Drosophila Aversive Behavior toward Erwinia carotovora carotovora Is Mediated by Bitter Neurons and Leukokinin.
Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Evolution of resistance and disease tolerance mechanisms to oral bacterial infection inOpen biology · 2025Article
- Larval microbiota primes the Drosophila adult gustatory response.Nature communications · 2024Article
- Tastant-receptor interactions: insights from the fruit fly.Frontiers in nutrition · 2024Review
- Metal-Organic Framework Optical Thermometer Based on CrACS applied materials & interfaces · 2023Article
- Enteric bacterial infection in Drosophila induces whole-body alterations in metabolic gene expression independently of the immune deficiency signaling pathway.G3 (Bethesda, Md.) · 2022Article
- Gut-derived peptidoglycan remotely inhibits bacteria dependent activation of SREBP by Drosophila adipocytes.PLoS genetics · 2022Article
- Review
- Leucokinin and Associated Neuropeptides Regulate Multiple Aspects of Physiology and Behavior inInternational journal of molecular sciences · 2021Review
- Leucokinins: Multifunctional Neuropeptides and Hormones in Insects and Other Invertebrates.International journal of molecular sciences · 2021Review
- Protocol for a Binary Choice Feeding Assay Using Adult, AxenicSTAR protocols · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phytopathogen Erwinia carotovora carotovora (Ecc) has been used successfully to decipher some of the mechanisms that regulate the interactions between Drosophila melanogaster and bacteria, mostly following forced association between the two species. How do Drosophila normally perceive and respond to the presence of Ecc is unknown. Using a fly feeding two-choice assay and video tracking, we show that Drosophila are first attracted but then repulsed by an Ecc-contaminated solution. The initial attractive phase is dependent on the olfactory Gr63a and Gαq proteins, whereas the second repulsive phase requires a functional gustatory system. Genetic manipulations and calcium imaging indicate that bitter neurons and gustatory receptors Gr66a and Gr33a are needed for the aversive phase and that the neuropeptide leukokinin is also involved. We also demonstrate that these behaviors are independent of the NF-κB cascade that controls some of the immune, metabolic, and behavioral responses to bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.