Catalytic Enantiodivergent Michael Addition by Subtle Adjustment of Achiral Amino Moiety of Dipeptide Phosphines.

Huamin Wang, Xiuzheng Li, Youshao Tu, Junliang Zhang

Abstract read

In one paragraph

Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

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3 · Its place in the literature

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1 citing paper in PubMed.

Recent progress in the chemistry of β-aminoketones.RSC advances · 2022
Review

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5 · Who and what money

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4 authors.

Huamin WangDepartment of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200438, P. R. China; Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, P. R. China.

Xiuzheng LiSchool of Pharmacy, Anhui Medical University, 81 N. Meishan Road, Hefei 230032, P. R.China.

Youshao TuCollege of Chemistry and Life Science, Advanced Institute of Materials Science, Changchun University of Technology, 2055 N. Yan'an Avenue, Changchun 130012, P. R. China.

Junliang ZhangDepartment of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200438, P. R. China; Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, P. R. China. Electronic address: junliangzhang@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past decades, asymmetric catalysis has been intensely investigated as a powerful tool for the preparation of numerous chiral biologically active compounds. However, developing general and practical strategies for preparation of both enantiomers of a chiral molecule via asymmetric catalysis is still a challenge, particularly when the two enantiomers of a chiral catalyst are not easily prepared from natural chiral sources. Inspired by the biologic system, we report herein an unprecedented catalytic enantiodivergent Michael addition of pyridazinones to enones by subtle adjustment of achiral amino moiety of dipeptide phosphine catalysts. These two dipeptide phosphine catalysts, P5 and P8, could deliver both enantiomers of a series of N

Indexed as

ChemistryOrganic ChemistryOrganic Chemistry Methods

Identifiers

PMID32450512

DOI10.1016/j.isci.2020.101138

PMCPMC7251764

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