Evidence map›Paper›PMID 32450444›Full record

ArticleNeurobiology of aging2020

Associations between cerebrospinal fluid total phosphatidylcholines, neurodegeneration, cognitive decline, and risk of mild cognitive impairment in the Mayo Clinic Study of Aging.

Danni Li, Clinton Hagen, Hai H Bui, David Knopman, Clifford R Jack, Mary Machulda, Ronald C Petersen, Michelle M Mielke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Neurobiological effects of phospholipidsNeurobiology of stress · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Danni LiDepartment of Lab Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Clinton HagenDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA.
Hai H BuiEli Lilly and Company, Indianapolis, IN, USA.
David KnopmanDepartment of Neurology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Clifford R JackDepartment of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Mary MachuldaDepartment of Psychiatry and Psychology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Ronald C PetersenDepartment of Neurology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Michelle M MielkeDepartment of Neurology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. Electronic address: mielke.michelle@mayo.edu.

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
PREDICTING ALZHEIMERS DISEASE WITH MAGNETIC RESONANCER01AG011378 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R. · 1993 to 2017
$12.1M
Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
Disease pathways in the population determined by amyloid, tau, and neurodegeneration imaging biomarkersR37AG011378 · NIA · MAYO CLINIC ROCHESTER · PI CLIFFORD R. JACK · 2018 to 2026
$6.8M
Validating the New Criteria for Preclinical Alzheimer's diseaseR01AG041851 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R., KNOPMAN, DAVID S · 2012 to 2021
$6.3M
Reproductive risk factors for Alzheimer's disease dementia and pathologyRF1AG055151 · NIA · MAYO CLINIC ROCHESTER · PI MIELKE, MICHELLE M, ROCCA, WALTER A · 2017 to 2017
$4.0M
Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR33AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2020 to 2022
$2.4M
Blood Biomarkers as Surrogate Endpoints of Treatment Responses to Aerobic Exercise and/or Cognitive Training in Amnestic Mild Cognitive ImpairmentR01AG059654 · NIA · UNIVERSITY OF MINNESOTA · PI LI, DANNI · 2018 to 2022
$2.2M
Sphingolipids and Inflammation in the Development and Progression of Alzheimer'sR01AG049704 · NIA · MAYO CLINIC ROCHESTER · PI MIELKE, MICHELLE M · 2015 to 2018
$1.5M
Identification of plasma hydroxysphingolipids as biomarkers of demyelination and neurodegeneration underlying physical function decline in older adultsR21AG059068 · NIA · UNIVERSITY OF MINNESOTA · PI LI, DANNI · 2018 to 2019
$449k
NIA NIH HHS R01 AG011378NIA NIH HHS R01 AG034676NIA NIH HHS R01 AG041851NIA NIH HHS R01 AG049704NIA NIH HHS R01 AG059654NIA NIH HHS R21 AG059068NIA NIH HHS R33 AG058738NIA NIH HHS R37 AG011378NIA NIH HHS RF1 AG055151NIA NIH HHS U01 AG006786
6 · The paper itself

Abstract

It is unclear whether cerebrospinal fluid (CSF) phosphatidylcholines (PCs) are associated with neuroimaging measures of amyloid deposition and neurodegeneration (glucose metabolism, cortical thickness, and hippocampal volume), cognitive decline, or risk of mild cognitive impairment (MCI) among cognitively unimpaired older adults. This study investigated the associations of 19 individual CSF PC concentrations and their total sum with cross-sectional and longitudinal measures of amyloid deposition and neurodegeneration, global and domain-specific cognitive z-scores, and risk of MCI among 655 cognitively unimpaired participants, mean age of 71 years, enrolled in the Mayo Clinic Study of Aging. Neither the CSF total PC concentration nor individual CSF PCs were cross-sectionally or longitudinally associated with neuroimaging measures, cognition, or risk of MCI.

Indexed as

AgingNegative ResultsAgedAmyloid beta-PeptidesBiomarkersBrainCognitive DysfunctionCross-Sectional StudiesFemaleHumansLongitudinal StudiesMalePhosphatidylcholinesRiskAmyloid beta-PeptidesBiomarkersPhosphatidylcholinesCerebrospinal fluidCognitionMild cognitive impairmentPhosphatidylcholines

Identifiers

PMID32450444
PMCPMC7302967

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.