ArticleAmerican journal of ophthalmology2021
Rates of Glaucomatous Structural and Functional Change From a Large Clinical Population: The Duke Glaucoma Registry Study.
Article in American journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 79 citations in OpenAlex.
- Visual Field Outcomes in the Primary Tube Versus Trabeculectomy Study.Ophthalmology · 2024Trial
- Artificial Intelligence-Guided Endpoint Selection for Neuroprotection Trials in Glaucoma.American journal of ophthalmology · 2026Article
- Structural and Functional Progression in Open-Angle Glaucoma with Unilateral Peripapillary Intrachoroidal Cavitation.Journal of clinical medicine · 2026Article
- Visual field progression in Asian glaucoma patients: a 10-year stratified cohort analysis from a national health system with universal coverage.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Proportion of Fast Progressors in the Central versus Global Visual Field Across Varying Glaucoma Severity Groups.American journal of ophthalmology · 2026Article
- Initial circumpapillary retinal nerve fibre layer rates of change predict glaucomatous progression.Eye (London, England) · 2025Article
- Inefficacy of Longitudinal Cup-to-Disc Ratio Measurements in Identifying Glaucoma Progression.American journal of ophthalmology · 2025Article
- Longitudinal Structural and Microvascular Imaging of Mouse Retina After Optic Nerve Crush Using Temporal Speckle-Averaging Visible Light OCT.Investigative ophthalmology & visual science · 2025Article
- Accelerated Epigenetic Aging Is Associated with Faster Glaucoma Progression: A DNA Methylation Study.Ophthalmology · 2025Article
- Impact of race and ethnicity on glaucoma progression detection by perimetry and optical coherence tomography.Scientific reports · 2024Article
- Association Between Greater Social Vulnerability and Delayed Glaucoma Surgery.American journal of ophthalmology · 2024Article
- Social history and glaucoma progression: the effect of body mass index, tobacco and alcohol consumption on the rates of structural change in patients with glaucoma.The British journal of ophthalmology · 2024Article
- Impact of Race and Ethnicity on Glaucoma Progression Detection by Perimetry and Optical Coherence Tomography.Research square · 2024Article
- Racial-ethnic disparities in concurrent rates of peripapillary & macular OCT parameters among a large glaucomatous clinical population.Eye (London, England) · 2024Article
- The Impact of Achieving Target Intraocular Pressure on Glaucomatous Retinal Nerve Fiber Layer Thinning in a Treated Clinical Population.American journal of ophthalmology · 2024Article
- Short-term Detection of Fast Progressors in Glaucoma: The Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study.Ophthalmology · 2024Article
- Longitudinal Rates of Change in Structural Parameters of Optical Coherence Tomography in Primary Angle Closure Glaucoma following Laser Iridotomy along with Peripheral Iridoplasty.Journal of ophthalmology · 2024Article
- Persistence with medical glaucoma therapy in newly diagnosed patients.Medical hypothesis, discovery & innovation ophthalmology journal · 2024Article
- Validating Trend-Based End Points for Neuroprotection Trials in Glaucoma.Translational vision science & technology · 2023Article
- Identifying Risk Factors for Blindness From Glaucoma at First Presentation to a Tertiary Clinic.American journal of ophthalmology · 2023Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate rates of structural and functional change in a large clinical population of glaucoma and glaucoma suspect patients.
designRetrospective cohort.
methodsTwenty-nine thousand five hundred forty-eight spectral-domain optical coherence tomography (OCT) and 19,812 standard automated perimetry (SAP) tests from 6138 eyes of 3669 patients with ≥6 months of follow-up, 2 good quality spectral-domain OCT peripapillary retinal nerve fiber layer scans, and 2 reliable SAP tests were included. Data were extracted from the Duke Glaucoma Registry, a large database of electronic health records of patients from the Duke Eye Center and satellite clinics. Rates of change for the 2 metrics were obtained using linear mixed models, categorized according to pre-established cutoffs, and analyzed according to the severity of the disease.
resultsAverage rates of change were -0.73 ± 0.80 μm per year for global retinal nerve fiber layer thickness and -0.09 ± 0.36 dB per year for SAP mean deviation. More than one quarter (26.6%) of eyes were classified as having at least a moderate rate of change by spectral-domain OCT vs 9.1% by SAP (P < .001). In eyes with severe disease, 31.6% were classified as progressing at moderate or faster rates by SAP vs 26.5% by spectral-domain OCT (P = .055). Most eyes classified as fast by spectral-domain OCT were classified as slow by SAP and vice versa.
conclusionAlthough most patients under routine care had slow rates of progression, a substantial proportion had rates that could potentially result in major losses if sustained over time. Both structural and functional tests should be used to monitor glaucoma, and spectral-domain OCT still has a relevant role in detecting fast progressors in advanced disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.