ArticleJournal of integrative plant biology2020
Co-regulation of indole glucosinolates and camalexin biosynthesis by CPK5/CPK6 and MPK3/MPK6 signaling pathways.
Article in Journal of integrative plant biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 70 citations in OpenAlex.
- Decoding MAPK cascades in plant immunity: Activation, regulation, integration, and pathogen manipulation.Journal of integrative plant biology · 2026Review
- MAPK regulates secondary metabolism and abiotic stress in horticultural and medicinal plants.Horticulture research · 2026Article
- Role of AtCPK5 and AtCPK6 in the regulation of the plant immune response triggered by rhamnolipids in Arabidopsis.PloS one · 2026Article
- Transcriptome analysis reveals key defense genes associated with resistance to banana blood disease.BMC genomics · 2025Article
- Pattern recognition receptors: function, regulation and therapeutic potential.Signal transduction and targeted therapy · 2025Review
- Insight into the Functional Role of SiMPK6 in Stress Response and Photosynthetic Efficiency inPlants (Basel, Switzerland) · 2025Article
- Comparative single-nucleus RNA-seq analysis revealed localized and cell type-specific pathways governing root-microbiome interactions.Nature communications · 2025Article
- Allelic Expression Dynamics of Regulatory Factors During Embryogenic Callus Induction in ABB Banana (Plants (Basel, Switzerland) · 2025Article
- Alternaria alternata effector AaAlta1 targets CmWD40 and participates in regulating disease resistance in Chrysanthemum morifolium.PLoS pathogens · 2025Article
- From Recognition to Response: Resistance-Effector Gene Interactions in thePlants (Basel, Switzerland) · 2025Review
- Natural variation in BnaA07.MKK9 confers resistance to Sclerotinia stem rot in oilseed rape.Nature communications · 2024Article
- WRKY33 negatively regulates anthocyanin biosynthesis and cooperates with PHR1 to mediate acclimation to phosphate starvation.Plant communications · 2024Article
- Article
- Sugar coordinates plant defense signaling.Science advances · 2024Article
- Comparative RNA-seq analysis of resistant and susceptible banana genotypes reveals molecular mechanisms in response to banana bunchy top virus (BBTV) infection.Scientific reports · 2023Article
- Altered methionine metabolism impacts phenylpropanoid production and plant development in Arabidopsis thaliana.The Plant journal : for cell and molecular biology · 2023Article
- Jasmonate signaling drives defense responses against Alternaria alternata in chrysanthemum.BMC genomics · 2023Article
- Plasma membrane-associated calcium signaling regulates arsenate tolerance in Arabidopsis.Plant physiology · 2023Article
- Insights to Gossypium defense response against Verticillium dahliae: the Cotton Cancer.Functional & integrative genomics · 2023Review
- Genetic approaches to dissect plant nonhost resistance mechanisms.Molecular plant pathology · 2023Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Secondary plant metabolites, represented by indole glucosinolates (IGS) and camalexin, play important roles in Arabidopsis immunity. Previously, we demonstrated the importance of MPK3 and MPK6, two closely related MAPKs, in regulating Botrytis cinerea (Bc)-induced IGS and camalexin biosynthesis. Here we report that CPK5 and CPK6, two redundant calcium-dependent protein kinases (CPKs), are also involved in regulating the biosynthesis of these secondary metabolites. The loss-of-function of both CPK5 and CPK6 compromises plant resistance to Bc. Expression profiling of CPK5-VK transgenic plants, in which a truncated constitutively active CPK5 is driven by a steroid-inducible promoter, revealed that biosynthetic genes of both IGS and camalexin pathways are coordinately upregulated after the induction of CPK5-VK, leading to high-level accumulation of camalexin and 4-methoxyindole-3-yl-methylglucosinolate (4MI3G). Induction of camalexin and 4MI3G, as well as the genes in their biosynthesis pathways, is greatly compromised in cpk5 cpk6 mutant in response to Bc. In a conditional cpk5 cpk6 mpk3 mpk6 quadruple mutant, Bc resistance and induction of IGS and camalexin are further reduced in comparison to either cpk5 cpk6 or conditional mpk3 mpk6 double mutant, suggesting that both CPK5/CPK6 and MPK3/MPK6 signaling pathways contribute to promote the biosynthesis of 4MI3G and camalexin in defense against Bc.
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