Evidence map›Paper›PMID 32449767›Full record

ReviewEndocrinology2020

Nuclear Receptor Coactivators (NCOAs) and Corepressors (NCORs) in the Brain.

Zheng Sun, Yong Xu

Open access · hybridAbstract readReview
In one paragraph

Review in Endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Review
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  11. Retinoic acid receptor assembly dynamics governs dual functions in cochlear organogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Review
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Zheng SunDepartment of Molecular and Cellular Biology; Baylor College of Medicine, Houston, Texas.
Yong XuDepartment of Molecular and Cellular Biology; Baylor College of Medicine, Houston, Texas.
Baylor College of Medicine · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
Tissue ResourceP50CA126752 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Leonid S Metelitsa · 2007 to 2026
$51.4M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
Translational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Casey W Wright · 2019 to 2026
$14.7M
Project 3: Coactivator-dependent hepatic 12h clock coordinates metabolic and stress rhythmsP01DK113954 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI O'MALLEY, BERT W · 2018 to 2022
$7.9M
Gender-Specific Effects of Arsenic in DiabetesR01ES027544 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI SUN, ZHENG · 2017 to 2021
$2.2M
Epigenomic Remodeling of Metabolism by Exercise through AP-1R01DK111436 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI SUN, ZHENG · 2017 to 2020
$2.0M
Hypothalamic Grb10 and body weightR01DK115761 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FRAZER, ALAN, XU, YONG · 2018 to 2021
$2.0M
Neurobiology for the sex differences in energy balanceR01DK117281 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2018 to 2022
$1.8M
De facto Target of Histone Deacetylase InhibitorsR21CA215591 · NCI · BAYLOR COLLEGE OF MEDICINE · PI SUN, ZHENG · 2017 to 2018
$345k
NCI NIH HHS P30 CA125123NCI NIH HHS P50 CA126752NCI NIH HHS R21 CA215591NIDDK NIH HHS P01 DK113954NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R01 DK111436NIDDK NIH HHS R01 DK115761NIDDK NIH HHS R01 DK117281NIEHS NIH HHS P30 ES030285NIEHS NIH HHS R01 ES027544
6 · The paper itself

Abstract

Nuclear receptor coactivators (NCOAs) and corepressors (NCORs) bind to nuclear hormone receptors in a ligand-dependent manner and mediate the transcriptional activation or repression of the downstream target genes in response to hormones, metabolites, xenobiotics, and drugs. NCOAs and NCORs are widely expressed in the mammalian brain. Studies using genetic animal models started to reveal pivotal roles of NCOAs/NCORs in the brain in regulating hormonal signaling, sexual behaviors, consummatory behaviors, exploratory and locomotor behaviors, moods, learning, and memory. Genetic variants of NCOAs or NCORs have begun to emerge from human patients with obesity, hormonal disruption, intellectual disability, or autism spectrum disorders. Here we review recent studies that shed light on the function of NCOAs and NCORs in the central nervous system.

Indexed as

AnimalsBehaviorBrainCo-Repressor ProteinsHumansNeurosecretory SystemsNuclear Receptor CoactivatorsTranscriptional ActivationCo-Repressor ProteinsNuclear Receptor Coactivatorsbehaviorbrainneuroendocrinenuclear receptor corepressor (NCOR)steroid receptor coactivator (SRC)

Identifiers

PMID32449767
PMCPMC7351129
OpenAlexW3026180445

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.