Evidence map›Paper›PMID 32449389›Full record

ArticleAutoimmunity2020

Decrease in alpha-1 antiproteinase antitrypsin is observed in primary Sjogren's syndrome condition.

Brij B Singh, Joyce Ohm, Fredice O Quenum Zanbede, Pooja Chauhan, Frans G M Kroese, Arjan Vissink, Julian L Ambrus, Bibhuti B Mishra

Open access · bronzeAbstract read
In one paragraph

Article in Autoimmunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Brij B SinghDepartment of Periodontics, School of Dentistry University of Texas Health Science Center, San Antonio, TX, USA.ORCID 0000-0003-0535-5997
Joyce OhmDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.
Fredice O Quenum ZanbedeDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.
Pooja ChauhanDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.
Frans G M KroeseDepartment of Rheumatology and Clinical Immunology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
Arjan VissinkDepartment of Oral and Maxillofacial Surgery, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
Julian L AmbrusDivision of Allergy, Immunology, and Rheumatology, Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY, USA.
Bibhuti B MishraDepartment of Periodontics, School of Dentistry University of Texas Health Science Center, San Antonio, TX, USA.
University of North Dakota · USThe University of Texas Health Science Center at San Antonio · USUniversity Medical Center Groningen · NLUniversity at Buffalo, State University of New York · US

Funding

Yersina perstis interactions with macrophagesP20GM113123 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI COMBS, COLIN K · 2016 to 2025
$19.9M
TRPC1, Calcium, and Saliva SecretionR01DE017102 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Brij B Singh · 2006 to 2026
$7.5M
Epigenetic regulations in Sjogern's syndromeR01DE022765 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SINGH, BRIJ B · 2017 to 2021
$1.8M
Galectins as novel alarmins in salivary gland inflammationR21DE024300 · NIDCR · UNIVERSITY OF NORTH DAKOTA · PI MISHRA, BIBHUTI BHUSAN, SINGH, BRIJ B · 2015 to 2016
$382k
NIDCR NIH HHS R01 DE017102NIDCR NIH HHS R01 DE022765NIDCR NIH HHS R21 DE024300NIGMS NIH HHS P20 GM113123
6 · The paper itself

Abstract

Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease that is characterized by the infiltration of immune cells. Although the loss of salivary gland function is a major manifestation observed in pSS, the factors that could promote these changes in salivary gland tissue in pSS is not yet determined. Herein, we provide evidence that loss of alpha

Indexed as

alpha 1-AntitrypsinAnimalsDNA MethylationFemaleHumansLeukocyte ElastaseLeukocytesMiceMice, TransgenicMicroRNAsSalivary GlandsSjogren's Syndromealpha 1-AntitrypsinLeukocyte ElastaseMicroRNAsMIRN132 microRNA, humanalpha-1 antiproteinase antitrypsinDNA methylationmicroRNAssalivary glandsSjogren’s syndrome

Identifiers

PMID32449389
PMCPMC7802062
OpenAlexW3026530848

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.