Evidence map›Paper›PMID 32449283›Full record

ArticleJournal of diabetes investigation2020

Risk of type 2 diabetes according to the cumulative exposure to metabolic syndrome or obesity: A nationwide population-based study.

You-Bin Lee, Da Hye Kim, Seon Mee Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Kyungdo Han, Hye Jin Yoo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

You-Bin LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Da Hye KimDepartment of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Seon Mee KimDepartment of Family Medicine, Korea University College of Medicine, Seoul, Korea.
Nan Hee KimDivision of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Kyung Mook ChoiDivision of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Sei Hyun BaikDivision of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Yong Gyu ParkDepartment of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kyungdo HanDepartment of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Hye Jin YooDivision of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-0600-0266
Korea University · KRCatholic University of Korea · KR

Funding

Ministry of EducationNational Research Foundation of Korea 2018R1D1A1B07047587
6 · The paper itself

Abstract

AIMS/

introductionWe investigated the risk of incident type 2 diabetes according to the cumulative exposure to obesity or metabolic syndrome (MetS) during annual or biennial health examinations. MATERIALS AND

methodsThe Korean National Health Insurance Service datasets from 2002 to 2017 were used for this retrospective longitudinal study. The risk for type 2 diabetes was analyzed according to the cumulative exposure to obesity and MetS among individuals who underwent four health examinations from 2009 to 2012 or 2013 (n = 2,851,745).

resultsDuring examinations, 28.56 and 17.86% of the total participants showed fluctuations in metabolic health state and obesity, respectively. During a mean 5.01 years of follow up, 98,950 new type 2 diabetes cases developed. The risk for type 2 diabetes increased with the increase in exposure to MetS (hazard ratio [HR] 2.92, 95% confidence interval [CI] 2.86-2.99; HR 4.96, 95% CI 4.85-5.08; HR 7.46, 95% CI 7.30-7.63; HR 12.24, 95% CI 12.00-12.49 in groups with number of exposures one to four, respectively) and obesity (HR 1.60, 95% CI 1.56-1.65; HR 1.87, 95% CI 1.81-1.92; HR 2.25, 95% CI 2.19-2.31; HR 3.46, 95% CI 3.41-3.51 in groups with number of exposures one to four, respectively), showing a more detrimental effect of cumulative exposure to MetS, when compared with the exposure to obesity.

conclusionsMetabolic health and obesity fluctuated within a relatively short period of 4-5 years. Although the impact was much greater for MetS than for obesity, the cumulative duration of both obesity and MetS was associated with an increased risk of type 2 diabetes in a dose-response manner. Therefore, continuously maintaining metabolic health and normal weight is crucial to prevent incident type 2 diabetes.

Indexed as

AdultAgedBiomarkersBlood GlucoseDiabetes Mellitus, Type 2FemaleFollow-Up StudiesHumansIncidenceLongitudinal StudiesMaleMetabolic SyndromeMiddle AgedObesityPrognosisRepublic of KoreaBiomarkersBlood GlucoseMetabolic syndromeObesityType 2 diabetes mellitus

Identifiers

PMID32449283
PMCPMC7610118
OpenAlexW3026247884

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.