Evidence map›Paper›PMID 32449273›Full record

ArticleAngewandte Chemie (International ed. in English)2020

Elucidation of the Intersystem Crossing Mechanism in a Helical BODIPY for Low-Dose Photodynamic Therapy.

Zhijia Wang, Ling Huang, Yuxin Yan, Ahmed M El-Zohry, Antonio Toffoletti, Jianzhang Zhao, Antonio Barbon, Bernhard Dick, Omar F Mohammed, Gang Han

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 229 citations in OpenAlex.

  1. Review
  2. Article
  3. Smart molecules : open access · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Exciton trapping with a twist.Chemical science · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Near-Infrared Conjugated Macrocyclic BODIPYs for Photothermal Cancer Therapy.Angewandte Chemie (International ed. in English) · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 5 countries.

Zhijia WangState Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, 2 Ling Gong Road, Dalian, 116024, China.ORCID 0000-0002-8309-0050
Ling HuangDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, 01605, USA.
Yuxin YanState Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, 2 Ling Gong Road, Dalian, 116024, China.ORCID 0000-0003-0487-8542
Ahmed M El-ZohryDivision of Physical Sciences and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Antonio ToffolettiDipartimento di Scienze Chimiche, Università degli Studi di Padova, Via Marzolo 1, 35121, Padova, Italy.
Jianzhang ZhaoState Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, 2 Ling Gong Road, Dalian, 116024, China.ORCID 0000-0002-5405-6398
Antonio BarbonDipartimento di Scienze Chimiche, Università degli Studi di Padova, Via Marzolo 1, 35121, Padova, Italy.ORCID 0000-0002-2009-5874
Bernhard DickLehrstuhl für Physikalische Chemie, Institut für Physikalische und Theoretische Chemie, Universität Regensburg, Universitätsstr. 31, 93053, Regensburg, Germany.ORCID 0000-0002-9693-5243
Omar F MohammedDivision of Physical Sciences and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Gang HanDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, 01605, USA.ORCID 0000-0002-2300-5862
Dalian University of Technology · CNKing Abdullah University of Science and Technology · SAUniversity of Massachusetts Chan Medical School · USUniversity of Padua · ITUniversity of Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intersystem crossing (ISC) of triplet photosensitizers is a vital process for fundamental photochemistry and photodynamic therapy (PDT). Herein, we report the co-existence of efficient ISC and long triplet excited lifetime in a heavy atom-free bodipy helicene molecule. Via theoretical computation and time-resolved EPR spectroscopy, we confirmed that the ISC of the bodipy results from its twisted molecular structure and reduced symmetry. The twisted bodipy shows intense long wavelength absorption (ϵ=1.76×10

Indexed as

PhotochemotherapyBoron CompoundsDose-Response Relationship, DrugElectron Spin Resonance SpectroscopyMolecular StructurePhotosensitizing AgentsQuantum Theory4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneBoron CompoundsPhotosensitizing Agentsbodipyintersystem crossingphotodynamic therapyphotosensitizerstwisted π-systems

Identifiers

PMID32449273
PMCPMC7540422
OpenAlexW3028348757

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.