Evidence map›Paper›PMID 32449248›Full record

ArticleEuropean journal of neurology2020

COVID-19 and herpes zoster co-infection presenting with trigeminal neuropathy.

A C A de F Ferreira, T T Romão, Y S Macedo, C Pupe, O J M Nascimento, Fellow of the American Academy of Neurology (FAAN)

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 3 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.

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  8. [Left mandibular osteonecrosis following herpes zoster of the third branch of left trigeminal nerve: A case report].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

A C A de F FerreiraSão Lucas Copacabana Hospital, Rio de Janeiro, Brazil.ORCID 0000-0001-8474-4557
T T RomãoSão Lucas Copacabana Hospital, Rio de Janeiro, Brazil.
Y S MacedoSão Lucas Copacabana Hospital, Rio de Janeiro, Brazil.
C PupeSão Lucas Copacabana Hospital, Rio de Janeiro, Brazil.
O J M NascimentoDepartment of Neurology, Fluminense Federal University, Rio de Janeiro, Brazil.
Fellow of the American Academy of Neurology (FAAN)
Universidade Federal Fluminense · BRHospital São Lucas da PUCRS · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVaricella-zoster virus (VZV) is a human neurotropic virus that remains in a latent state within ganglionic neurons throughout the entire neuroaxis after the primary infection. When herpes zoster (HZ) leads to trigeminal involvement, the ophthalmic division is the most implicated. COVID-19 has emerged as a viral cause of severe acute respiratory syndrome that has spread all over the world in the last months. Co-infection with COVID-19 and other viruses has been reported, but sparsely, and involving the respiratory viruses.

methodsThe case of a co-infection of COVID-19 with VZV is reported, and the literature reviewed.

resultsA 39-year-old immunocompetent man presented with oligosymptomatic infection with COVID-19, which evolved to left facial HZ, affecting the three divisions of the trigeminal nerve. The co-infection was remotely registered, being the respiratory viruses, especially influenza, the most commonly cited association. However, the present case illustrates the emergence of a latent virus infection, which might be favored by the inflammatory response to the former agent (COVID-19). This reaction ascended from the nasal cavity, where trigeminal branches are also placed.

conclusionsThe emergence of latent VZV infection in this rare presentation might illustrate an effect, at least locally, of COVID-19. This virus possibly induced a retrograde reactivation of VZV in a young immunocompetent patient.

Indexed as

AdultCoinfectionCOVID-19Herpes ZosterHumansMaleTrigeminal Nerve Diseasesco-infectionCOVID-19herpes zostertrigeminal

Identifiers

PMID32449248
PMCPMC7283788
OpenAlexW3028281389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.