Evidence map›Paper›PMID 32449237›Full record

SynthesisTransplant infectious disease : an official journal of the Transplantation Society2020

Antifungal prophylaxis in lung transplant recipients: A systematic review and meta-analysis.

Kelly M Pennington, Misbah Baqir, Patricia J Erwin, Raymund R Razonable, Mohammad Hassan Murad, Cassie C Kennedy

Open access · greenAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Transplant infectious disease : an official journal of the Transplantation Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Fungal infections in lung transplantation.Journal of thoracic disease · 2021
    Review
  8. The Impact of Antifungal Prophylaxis in Lung Transplant Recipients.Annals of the American Thoracic Society · 2021
    Article
  9. Review
  10. Review
  11. An Update on Invasive Fungal Infections in Solid Organ Transplant Recipients.Transplant infectious disease : an official journal of the Transplantation Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kelly M PenningtonDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0003-1187-5059
Misbah BaqirDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Patricia J ErwinDepartment of Library Services, Mayo Clinic, Rochester, Minnesota, USA.
Raymund R RazonableWilliam J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0001-5248-0227
Mohammad Hassan MuradRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota, USA.
Cassie C KennedyDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Mayo Clinic · USMayo Clinic in Arizona · US

Funding

Exploring the Unmeasured Risk and Treating the Untreated Prognostic Factor: Towards Candidate Optimization in Heart and Lung TransplantK23HL128859 · NHLBI · MAYO CLINIC ROCHESTER · PI KENNEDY, CASSIE COLLEEN · 2016 to 2020
$854k
NHLBI NIH HHS K23 HL128859Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MNTheThe National Heart, Lung, And Blood Institute of the National Institutes of Health K23HL128859
6 · The paper itself

Abstract

backgroundNo consensus exists regarding optimal strategy for antifungal prophylaxis following lung transplant.

objectiveTo review data regarding antifungal prophylaxis on the development of fungal infections. STUDY SELECTION/APPRAISAL: We searched MEDLINE, Embase, and Scopus for eligible articles through December 10, 2019. Observational or controlled trials published after January 1, 2001, that pertained to the prevention of fungal infections in adult lung recipients were reviewed independently by two reviewers for inclusion.

methodsOf 1702 articles screened, 24 were included. Data were pooled using random effects model to evaluate for the primary outcome of fungal infection. Studies were stratified by prophylactic strategy, medication, and duration (short term < 6 months and long term ≥ 6 months).

resultsWe found no difference in the odds of fungal infection with universal prophylaxis (49/101) compared to no prophylaxis (36/93) (OR 0.76, CI: 0.03-17.98; I

conclusionsWe have insufficient evidence to support or exclude a benefit of antifungal prophylaxis.

Indexed as

Antifungal AgentsChemopreventionHumansImmunocompromised HostLungLung TransplantationMycosesTransplantation, HomologousTransplant RecipientsTreatment OutcomeAntifungal Agentsaspergillusfungal infectionlung transplantprophylaxis

Identifiers

PMID32449237
PMCPMC7415601
OpenAlexW3026072426

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.