Evidence map›Paper›PMID 32449113›Full record

ArticleHuman cell2020

Biological assessment of new tetrahydroacridine derivatives with fluorobenzoic moiety in vitro on A549 and HT-29 cell lines and in vivo on animal model.

Karol Kłosiński, Małgorzata Girek, Kamila Czarnecka, Zbigniew Pasieka, Robert Skibiński, Paweł Szymański

Open access · hybridAbstract read
In one paragraph

Article in Human cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Experiments and Calculation on New N,N-Molecules (Basel, Switzerland) · 2024
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Karol KłosińskiDepartment of Experimental Surgery, Faculty of Medicine, Medical University of Lodz, Narutowicza 60, 90-136, Lodz, Poland.
Małgorzata GirekDepartment of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151, Lodz, Poland.
Kamila CzarneckaDepartment of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151, Lodz, Poland.
Zbigniew PasiekaDepartment of Experimental Surgery, Faculty of Medicine, Medical University of Lodz, Narutowicza 60, 90-136, Lodz, Poland.
Robert SkibińskiDepartment of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 4, 20-090, Lublin, Poland.
Paweł SzymańskiDepartment of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151, Lodz, Poland. pawel.szymanski@umed.lodz.pl.ORCID http://orcid.org/0000-0003-3438-7509
Medical University of Lodz · PLMedical University of Lublin · PL

Funding

Uniwersytet Medyczny w Lodzi (502-02/3-015-01 /502-34-091)Uniwersytet Medyczny w Lodzi (502-03/1-153-02/502-14-325)
6 · The paper itself

Abstract

A new series of tetrahydroacridine derivatives with the fluorobenzoyl moiety was synthesized and evaluated for cytotoxic activity against lung cancer cell lines A549 and colorectal cancer HT29. The cytotoxic activity of the compounds was compared on the somatic cell line-EAhy926. Compounds showed high cytotoxic activity on A549 cells (IC

Indexed as

AcridinesAnimalsCell Line, TumorColorectal NeoplasmsDisease Models, AnimalFluorobenzenesHumansHyaluronoglucosaminidaseLethal Dose 50Lung NeoplasmsMiceRatsToxicity TestsAcridinesFluorobenzenesHyaluronoglucosaminidaseAcridine derivativesColorectal cancerCytotoxicityLung cancerMTT assay

Identifiers

PMID32449113
PMCPMC7324419
OpenAlexW3026080348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.