Evidence map›Paper›PMID 32449094›Full record

ArticleJournal of endocrinological investigation2021

Body composition and bone status in relation to microvascular damage in systemic sclerosis patients.

S Paolino, E Gotelli, F Goegan, A Casabella, G Ferrari, M Patane, M Albertelli, F Gatto, C Pizzorni, F Cattelan and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Body composition and microvascular damage in systemic sclerosis patients.Journal of endocrinological investigation · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

S PaolinoDepartment of Internal Medicine DiMI, Research Laboratory and Academic Division of Clinical Rheumatology, University of Genoa, IRCCS San Martino Polyclinic, Genoa, Italy. sabrina.paolino@unige.it.
E GotelliDepartment of Internal Medicine DiMI, Research Laboratory and Academic Division of Clinical Rheumatology, University of Genoa, IRCCS San Martino Polyclinic, Genoa, Italy.
F GoeganDepartment of Internal Medicine DiMI, Research Laboratory and Academic Division of Clinical Rheumatology, University of Genoa, IRCCS San Martino Polyclinic, Genoa, Italy.
A CasabellaDepartment of Internal Medicine DiMI, Research Laboratory and Academic Division of Clinical Rheumatology, University of Genoa, IRCCS San Martino Polyclinic, Genoa, Italy.
G FerrariDepartment of Internal Medicine DiMI, Research Laboratory and Academic Division of Clinical Rheumatology, University of Genoa, IRCCS San Martino Polyclinic, Genoa, Italy.
M PataneDepartment of Internal Medicine DiMI, Research Laboratory and Academic Division of Clinical Rheumatology, University of Genoa, IRCCS San Martino Polyclinic, Genoa, Italy.
M AlbertelliEndocrinology Unit, IRCCS Policlinico San Martino, Genoa, Italy.
F GattoEndocrinology Unit, IRCCS Policlinico San Martino, Genoa, Italy.
C PizzorniDepartment of Internal Medicine DiMI, Research Laboratory and Academic Division of Clinical Rheumatology, University of Genoa, IRCCS San Martino Polyclinic, Genoa, Italy.
F CattelanDepartment of Internal Medicine DiMI, Research Laboratory and Academic Division of Clinical Rheumatology, University of Genoa, IRCCS San Martino Polyclinic, Genoa, Italy.
A SulliDepartment of Internal Medicine DiMI, Research Laboratory and Academic Division of Clinical Rheumatology, University of Genoa, IRCCS San Martino Polyclinic, Genoa, Italy.
V Smith *Department of Internal Medicine, Ghent University, Ghent, Belgium.
M Cutolo *Department of Internal Medicine DiMI, Research Laboratory and Academic Division of Clinical Rheumatology, University of Genoa, IRCCS San Martino Polyclinic, Genoa, Italy.
Ospedale Policlinico San Martino · ITUniversity of Genoa · ITVIB-UGent Center for Inflammation Research · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate, in Systemic sclerosis (SSc) patients, the body composition and the bone status according to the peripheral microcirculatory condition, assessed and scored by nailfold videocapillaroscopy (NVC, "Early", "Active", "Late" patterns).

methodsBody composition and bone mineral density (BMD) were assessed by Dual X-ray absorptiometry and dedicated software (GE Lunar USA) in 37 female SSc patients classified according to the 2013 EULAR/ACR criteria and 40 sex-matched healthy subjects. Clinical, laboratory, body composition and bone parameters were analyzed according to the different NVC patterns. Means were compared by the Student's t test or one-way analysis of variance; medians were compared by the Kruskal-Wallis test; and frequencies by the chi-square test.

resultsHigher prevalence of vertebral (21% vs 7%) and femoral (35% vs 7%) osteoporosis (OP) was found in SSc. Particularly SSc patients with "Late" NVC pattern showed a significantly higher prevalence of vertebral (p = 0.018) and femoral OP (p = 0.016). Regional assessment of bone mass (BM) in seven different body areas showed a significantly lower BMD only at the total spine (p = 0.008) and femoral neck (p = 0.027) in advanced microvascular damage. Patients with "Late" NVC pattern showed a lower whole-body lean mass (LM) compared to "Early" and "Active" NVC patterns, particularly at upper limbs. To note, in all body sites, BMD correlates with LM and BMC according to NVC pattern severity.

conclusionsSSc patients with most severe microvascular damage show a significantly altered body composition and bone status suggesting a strong link between microvascular failure and associated muscle/bone sufferance.

Indexed as

MicrocirculationAgedBody CompositionBone Diseases, MetabolicCase-Control StudiesFemaleFollow-Up StudiesHumansItalyMaleMiddle AgedOsteoporosisPrognosisRetrospective StudiesScleroderma, SystemicBody compositionBone mineral densityCapillaroscopyConnective tissue diseasesRheumatic diseasesSarcopeniaSystemic sclerosis

Identifiers

PMID32449094
OpenAlexW3028172989

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.