Evidence map›Paper›PMID 32449067›Full record

ArticleGenes & genomics2020

The role of CTNNB1 and LEF1 in feather follicles development of Anser cygnoides and Anser anser.

Yue Sun, Yuxuan Zhou, Petunia Msuthwana, Jing Liu, Chang Liu, Cornelius Tlotliso Sello, Yupu Song, Ziqiang Feng, Shengyi Li, Wei Yang and 6 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Genes & genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Effects ofAnimals : an open access journal from MDPI · 2025
    Article
  3. Article
  4. Genes · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Yue SunDepartment of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street, No: 2888, Changchun, 130118, People's Republic of China.
Yuxuan ZhouDepartment of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street, No: 2888, Changchun, 130118, People's Republic of China.
Petunia MsuthwanaDepartment of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street, No: 2888, Changchun, 130118, People's Republic of China.
Jing LiuDepartment of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street, No: 2888, Changchun, 130118, People's Republic of China.
Chang LiuDepartment of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street, No: 2888, Changchun, 130118, People's Republic of China.
Cornelius Tlotliso SelloDepartment of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street, No: 2888, Changchun, 130118, People's Republic of China.
Yupu SongDepartment of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street, No: 2888, Changchun, 130118, People's Republic of China.
Ziqiang FengDepartment of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street, No: 2888, Changchun, 130118, People's Republic of China.
Shengyi LiDepartment of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street, No: 2888, Changchun, 130118, People's Republic of China.
Wei YangDepartment of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street, No: 2888, Changchun, 130118, People's Republic of China.
Yunpeng XuDepartment of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street, No: 2888, Changchun, 130118, People's Republic of China.
Xiaomin YanDepartment of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street, No: 2888, Changchun, 130118, People's Republic of China.
Chuanghang LiDepartment of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street, No: 2888, Changchun, 130118, People's Republic of China.
Yujian SuiDepartment of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street, No: 2888, Changchun, 130118, People's Republic of China.
Jingtao HuDepartment of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street, No: 2888, Changchun, 130118, People's Republic of China.
Yongfeng SunDepartment of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street, No: 2888, Changchun, 130118, People's Republic of China. sunyongfeng1977@126.com.
Jilin Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWingless-types/beta-catenin (Wnt/β-catenin) signaling pathway is one of the most extensively studied transcriptional cascades involved in various types of organogenesis including embryonic and postnatal development. Downy feather quantity is primarily affected by follicular development and gene regulations.

objectiveThis research was aimed to investigate the role of catenin beta-1(CTNNB1) and lymphoid enhancerbinding factor-1 (LEF1) on feather follicles development at different developmental stages.

methodsFluorescence quantitative PCR, Western-blot and immunohistochemical methods were used in Anser cygnoides and Anser anser embryos (E12, E13 E18, and E28) and after birth gosling stages (G18, G48, G88) for gene expression analysis.

resultsCTNNB1 and LEF1 genes were expressed in Anser cygnoides and Anser anser at different embryonic and after-birth gosling developmental stages and the expression levels were significantly different in different stages (p < 0.05). The mRNA expression of CTNNB1 and LEF1 genes reached the highest level at D88 in Anser cygnoides, while the highest expression levels were at D18 and D88 in Anser anser, and the expression levels of CTNNB1 genes at D88 in all embryonic stages were significantly lower than after-birth stages. CTNNB1 and LEF1 protein expression were the highest at E12 and E28 for Anser cygnoides feather follicles development. While at a similar stage for Anser anser, the expression of CTNNB1 and LEF1 protein was the highest at D48 and D18. Protein expression at embryonic stages was in the epidermis (E) and the hair basal plate (P), the expression site for after-birth stages was in the dermal papilla (DP).

conclusionOur study illustrated that CTNNB1 and LEF1 has an impact on Anser cygnoides and Anser anser feather follicles growth and development.

Indexed as

Animalsbeta CateninFeathersGeeseGene Expression Regulation, DevelopmentalLymphoid Enhancer-Binding Factor 1OrganogenesisWnt Signaling Pathwaybeta CateninLymphoid Enhancer-Binding Factor 1Anser anserAnser cygnoidesCTNNB1Feather follicle developmentLEF1Wnt

Identifiers

PMID32449067
OpenAlexW3028273095

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.