Evidence map›Paper›PMID 32449050›Full record

ArticleHeart and vessels2020

Oscillating shear stress mediates mesenchymal transdifferentiation of EPCs by the Kir2.1 channel.

Jifeng Li, Yanting He, Hongnan Bu, Meiyue Wang, Jie Yu, Lanlan Li, Hong Li, Xiaoyun Zhang, Xiaodong Cui, Min Cheng

Abstract read
PubMed Publisher
In one paragraph

Article in Heart and vessels, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jifeng LiSchool of Basic Medical Sciences, Weifang Medical University, Weifang, 261053, Shandong, People's Republic of China.
Yanting HeSchool of Basic Medical Sciences, Weifang Medical University, Weifang, 261053, Shandong, People's Republic of China.
Hongnan BuDepartment of Gynaecology and Obstetrics, The 89 Hospital of Chinese PLA, Weifang, 261021, Shandong, People's Republic of China.
Meiyue WangSchool of Basic Medical Sciences, Weifang Medical University, Weifang, 261053, Shandong, People's Republic of China.
Jie YuSchool of Basic Medical Sciences, Weifang Medical University, Weifang, 261053, Shandong, People's Republic of China.
Lanlan LiSchool of Basic Medical Sciences, Weifang Medical University, Weifang, 261053, Shandong, People's Republic of China.
Hong LiSchool of Basic Medical Sciences, Weifang Medical University, Weifang, 261053, Shandong, People's Republic of China.
Xiaoyun ZhangSchool of Basic Medical Sciences, Weifang Medical University, Weifang, 261053, Shandong, People's Republic of China.
Xiaodong CuiSchool of Basic Medical Sciences, Weifang Medical University, Weifang, 261053, Shandong, People's Republic of China. xiaodongcui@wfmc.edu.cn.ORCID http://orcid.org/0000-0001-5023-4890
Min ChengSchool of Basic Medical Sciences, Weifang Medical University, Weifang, 261053, Shandong, People's Republic of China. mincheng@wfmc.edu.cn.
Weifang Medical University · CNWeifang People's Hospital · CN

Funding

National Natural Science Foundation of China 31570941National Natural Science Foundation of China 81700406National Natural Science Foundation of China 81870237Natural Science Foundation of Shandong Province ZR2014JL018Natural Science Foundation of Shandong Province ZR2016CM20Shandong Education Science Plan J15LK08
6 · The paper itself

Abstract

Although endothelial progenitor cells (EPCs) are considered to be an essential source of vascular endothelial repair, their bidirectional differentiation determines that they play a double-edged role in the restoration of endothelial injury. In this research, we investigated the effect of Kir2.1 ion channel on the transdifferentiation of endothelial progenitor cells (EPCs) under the oscillating shear stress (OSS) and the molecular mechanisms underlying the pathological vascular remodeling. EPCs were treated with OSS (± 3.5 dynes/cm

Indexed as

Epithelial-Mesenchymal TransitionMechanotransduction, CellularVascular RemodelingAnimalsCarotid Artery InjuriesCells, CulturedDisease Models, AnimalEndothelial Progenitor CellsNeovascularization, PhysiologicPotassium Channels, Inwardly RectifyingRats, Sprague-DawleyStress, MechanicalKCNJ2 protein, ratPotassium Channels, Inwardly RectifyingEndothelial progenitor cellsInward rectifier potassium channelMesenchymal cellsOscillatory shear stressTransdifferentiation

Identifiers

PMID32449050
OpenAlexW3026954808

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.