SynthesisInternational orthopaedics2020
Culture-negative periprosthetic joint infection: prevalence, aetiology, evaluation, recommendations, and treatment.
Synthesis in International orthopaedics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Diagnostic accuracy of the monocyte-to-lymphocyte ratio in periprosthetic joint infection: a systematic review and meta-analysis.Archives of orthopaedic and trauma surgery · 2025Pooled it
- Outcomes of culture-negative or -positive periprosthetic joint infections: A systematic review and meta-analysis.Joint diseases and related surgery · 2024Pooled it
- Diagnostic Value of Next-Generation Sequencing in Periprosthetic Joint Infection: A Systematic Review.Orthopaedic surgery · 2022Pooled it
- Periprosthetic hip and knee infections.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- Complement factors C3 and C5 as tissue biomarkers for differentiating periprosthetic joint infection from aseptic implant failure.European journal of microbiology & immunology · 2026Article
- Review
- Preoperative predictors of spacer retention and mortality in two-stage revision for infected total hip arthroplasties: a single-center experience of 90 patients.Arthroplasty (London, England) · 2026Article
- Microbiological Patterns in Periprosthetic Knee Infections over a Decade: Analysis of Resistance Patterns, Temporal Trends, and Patient Residence.Antibiotics (Basel, Switzerland) · 2026Article
- Delayed sacroiliac joint infection after robot-assisted percutaneous iliac screw fixation for tile type C2 pelvic fractures: A case report and literature review.The Journal of international medical research · 2026Review
- Clinical comparison of the BIOFIRE Joint Infection Panel using synovial fluid and tissue biopsy samples.Microbiology spectrum · 2026Article
- Six-Week Protocol for Two-Stage Exchange Arthroplasty in a High-Risk Population.Arthroplasty today · 2026Article
- Evaluating the Effect of Therapeutic Antibiotics in Prosthetic Joint Infections Culturing: A Narrative Review.Health science reports · 2026Article
- The presence of a positive blood culture should be regarded a risk factor for DAIR failure in cases of haematogenous total knee arthroplasty infection.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2026Article
- Optimization of sampling protocol, specimen types, and sampling sites in periprosthetic joint infections: a retrospective study.Journal of orthopaedic surgery and research · 2026Article
- From serum inflammatory markers to fluid, tissue, and molecular assays: current advances in the laboratory diagnosis of bone and joint infections.Frontiers in cellular and infection microbiology · 2026Review
- Management and outcomes of culture-negative periprosthetic joint infection: a systematic review and meta-analysis.Journal of bone and joint infection · 2026Article
- Culture-negative periprosthetic joint infection: an umbrella review of prevalence, diagnostic strategies, treatment, and methodological limitations.Journal of bone and joint infection · 2026Review
- Synovial Fluid MicroRNA Biomarkers Enable Accurate Diagnosis of Hip and Knee Periprosthetic Joint Infections.The Journal of bone and joint surgery. American volume · 2025Article
- Microbiological Profiles of Patients with Acute Periprosthetic Joint Infection Undergoing Debridement, Antibiotics, Irrigation and Implant Retention (DAIR).Antibiotics (Basel, Switzerland) · 2025Article
- Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePeriprosthetic joint infection (PJI) is a catastrophic complication after total joint arthroplasty (TJA). Treatment of PJI is challenging, especially when causative microorganism is not identified. The purpose of this systematic review was to guide diagnostic approach and treatment of culture-negative (CN) PJI.
methodsA systematic review was undertaken on clinical studies from MEDLINE, EMBASE, Cochrane Library, and Scopus databases. Basic science studies, letters, studies written in languages other than English, case reports, and review articles were excluded.
resultsProportion of CN PJI ranged from 5 to 42% of PJIs. Risk factors for culture negativity included prior use of antibiotic before culture test, inappropriate culture tools, insufficient culture period, and post-operative wound drainage. Specific diagnostic protocols including repeating sampling, longer incubation period, culture in blood culture bottles, sonication of implants, polymerase chain reaction in synovial fluid, and next-generation sequencing are recommended to identify undetected microorganisms. Vancomycin and cephalosporins are the most commonly used antibiotics. Two-stage revision arthroplasty showed success rate of 70-100%.
conclusionsA comprehensive review was performed to provide an up-to-date, evidence-based guide to the management of CN PJI.
Indexed as
Identifiers
32449042What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.