ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2020
An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics in China.
Abstract readMulticenter Study
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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 52 citations in OpenAlex.
- Machine learning for screening laryngopharyngeal reflux symptoms in college students: a cross-sectional study.Annals of medicine · 2026Article
- Preliminary study on symptoms and signs of patients with laryngopharyngeal reflux disease infected withExperimental and therapeutic medicine · 2026Article
- Laryngopharyngeal Symptoms and Laryngopharyngeal Reflux Disease: Presentation, Health Care Burden, and Risk Stratification.Neurogastroenterology and motility · 2026Review
- Interpretable Machine Learning for LPR Risk Estimation: A Single-Center Retrospective Case-Control Study.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- Low pillow height is associated with LPR among patients with GERD: a retrospective single-center study.BMC gastroenterology · 2025Article
- Diagnostic value of fasting hypopharyngeal salivary pepsin concentration test for laryngopharyngeal reflux disease.World journal of otorhinolaryngology - head and neck surgery · 2025Article
- [Treatment status and progress of laryngopharyngeal reflux disease].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Article
- Bama pig is a suitable animal for studying laryngopharyngeal reflux disease.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025Article
- Weak acid and pepsin reflux induce laryngopharyngeal mucosal barrier injury: A rabbit-model-based study.PloS one · 2025Article
- The reflux symptom score has good screening value for laryngopharyngeal reflux.BMC gastroenterology · 2024Observational
- Assessing the role of dryness and burning sensation in diagnosing laryngopharyngeal reflux.Scientific reports · 2024Article
- Elevated Saliva Pepsin Concentration as a Risk Factor for Asthma in Children with Allergic Rhinitis: A Preliminary Study.Journal of asthma and allergy · 2024Article
- Practical multidisciplinary framework for the assessment and management of patients with unexplained chronic aerodigestive symptoms.BMJ open gastroenterology · 2023Review
- Xerostomia, sticky saliva and dysphonia.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- [The application progress on diagnostic scales of laryngopharyngeal reflux disease].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023Review
- Pepsin concentration in oral lavage fluid of rabbit reflux model constructed by dilating the lower esophageal sphincter.Open medicine (Warsaw, Poland) · 2023Article
- Does hypopharyngeal-esophageal multichannel intraluminal impedance-pH monitoring for the diagnosis of laryngopharyngeal reflux have to be 24 h?European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Awareness about laryngopharyngeal reflux disease among Chinese otolaryngologists: a nationwide survey.BMJ open · 2022Article
- Article
- Correlation and Influencing Factors Between Laryngopharyngeal Reflux Disease and Sleep Status in Patients.Frontiers in surgery · 2022Article
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Authors and funding
75 authors at 20 institutions in 1 country.
Shuifang XiaoDepartment of Otorhinolaryngology, Head and Neck Surgery, Peking University First Hospital, 8# Xishiku Street, Western District, Beijing, 100034, China. xiao_ent@163.com.ORCID http://orcid.org/0000-0003-1554-9859
Jinrang LiDepartment of Otorhinolaryngology, Head and Neck Surgery, The Sixth Medical Center of Chinese PLA General Hospital, 6# Fucheng Road, Haidian District, Beijing, 100048, China. entljr@sina.com.
Hongliang ZhengDepartment of Otorhinolaryngology, Head and Neck Surgery, Changhai Hospital, Second Military Medical University, 168# Changhai Street, Yangpu District, Shanghai, 200433, China. zheng_hl2004@163.com.
Yan YanDepartment of Otorhinolaryngology, Head and Neck Surgery, Peking University Third Hospital, Beijing, China.
Xiangping LiDepartment of Otorhinolaryngology, Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Lihong ZhangDepartment of Otorhinolaryngology, Head and Neck Surgery, Peking University People's Hospital, Beijing, China.
Quiping LvDepartment of Otorhinolaryngology, Head and Neck Surgery, China-Japan Friendship Hospital, Beijing, China.
Junbo ZhangDepartment of Otorhinolaryngology, Head and Neck Surgery, Peking University First Hospital, 8# Xishiku Street, Western District, Beijing, 100034, China.
Lin ZengResearch Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, China.
Xia GaoDepartment of Otorhinolaryngology, Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.
Xiong ChenDepartment of Otorhinolaryngology, Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Hui YangDepartment of Otorhinolaryngology, Head and Neck Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Chen ZhaoDepartment of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Jian ZhangDepartment of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Honghua LuDepartment of Otorhinolaryngology, Head and Neck Surgery, Tianjin First Central Hospital, Tianjin, China.
Xianyang LuoDepartment of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
Guangke WangDepartment of Otorhinolaryngology Head and Neck Surgery, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Hongliang YiDepartment of Otorhinolaryngology, Head and Neck Surgery, Affiliated Sixth People's Hospital of Shanghai Jiaotong University, Shanghai, China.
Jin YeDepartment of Otorhinolaryngology, Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Zhenqun LinDepartment of Otorhinolaryngology, Head and Neck Surgery, Hainan Provincial People's Hospital, Hiakou, Hainan, China.
Linli TianDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Jingjing ZhangDepartment of Otorhinolaryngology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
Ting ChenDepartment of Otorhinolaryngology, Head and Neck Surgery, Fujian Provincial Hospital, Fuzhou, Fujian, China.
Aimin YuDepartment of Otorhinolaryngology, Head and Neck Surgery, Clinical Medical School, Yangzhou University, Yangzhou, Jiangsu, China.
Zhaohui LiuDepartment of Otorhinolaryngology, Head and Neck Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, China.
Xiaoyong RenDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Xinming YangDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Siyi ZhangDepartment of Otorhinolaryngology Head and Neck Surgery, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China.
Xiaobo CuiDepartment of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Gelin LiDepartment of Otorhinolaryngology, Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Guanglun WanDepartment of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Hospital, Hefei, Anhui, China.
Chang LinDepartment of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Hui ChenDepartment of Otorhinolaryngology, Head and Neck Surgery, Chengdu First People's Hospital, Chengdu, Sichuan, China.
Anchun DengDepartment of Otorhinolaryngology, Head and Neck Surgery, Xinqiao Hospital, Army Military Medical University, Chongqing, China.
Xiabing TangDepartment of Otorhinolaryngology, Head and Neck Surgery, Wuxi People's Hospital, Wuxi, Jiangsu, China.
Qingfeng ZhangDepartment of Otorhinolaryngology, Head and Neck Surgery, Dalian Central Hospital, Dalian, Liaoning, China.
Zhenfeng TaoDepartment of Otorhinolaryngology, Head and Neck Surgery, Bethune International Peace Hospital, Shijiazhuang, Hebei, China.
Li ShiDepartment of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi, China.
Jianyong ZhouDepartment of Otorhinolaryngology Head and Neck Surgery, Jiangmen Central Hospital, Jiangmen, Guangdong, China.
Gang QinDepartment of Otorhinolaryngology, Head and Neck Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Peiyun ZhuangDepartment of Voice, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China.
Hui HuangfuDepartment of Otorhinolaryngology, Head and Neck Surgery, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Jianming YangDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Guojin ZhouDepartment of Otorhinolaryngology, Head and Neck Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Huijun LiDepartment of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Wei WuDepartment of Otorhinolaryngology, Head and Neck Surgery, PLA Strategic Support Force Characteristic Medical Center, Beijing, China.
Julan LiDepartment of Otorhinolaryngology Head and Neck Surgery, Sichuan Provincial Corps Hospital, Chinese People's Armed Police Force, Leshan, Sichuan, China.
Shuhua LiDepartment of Otorhinolaryngology Head and Neck Surgery, General Hospital of Northern Theater Command, Shenyang, Liaoning, China.
Guangming LouDepartment of Otorhinolaryngology Head and Neck Surgery, The First Hospital of Longyan City, Longyan, Fujian, China.
Hongyan FangDepartment of Otorhinolaryngology Head and Neck Surgery, Chongqing General Hospital, Chongqing, China.
Jiangang MaDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Chunguang ShanDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Xuejun ZhouDepartment of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Hainan Medical College, Haikou, Hainan, China.
Liang TangDepartment of Otorhinolaryngology, Head and Neck Surgery, The People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
Fang ZhouDepartment of Otorhinolaryngology Head and Neck Surgery, Changsha Central Hospital, Changsha, Hunan, China.
Yunping FanDepartment of Otorhinolaryngology Head and Neck Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Yanping ZhangDepartment of Otorhinolaryngology Head and Neck Surgery, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China.
Yujie LiDepartment of Otorhinolaryngology Head and Neck Surgery, Zhengzhou Central Hospital, Zhengzhou, Henan, China.
Meisheng LiDepartment of Otorhinolaryngology Head and Neck Surgery, The First People's Hospital of Shangqiu City, Shangqiu, Henan, China.
Chunqiang DouDepartment of Otorhinolaryngology, Head and Neck Surgery, Linfen People's Hospital, Linfen, Shanxi, China.
Zhiling ChenDepartment of Otorhinolaryngology, Head and Neck Surgery, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, China.
Gang LeiDepartment of Otorhinolaryngology Head and Neck Surgery, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.
Jingbo LiDepartment of Otorhinolaryngology Head and Neck Surgery, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, Henan, China.
Zhiguang GaoDepartment of Otorhinolaryngology Head and Neck Surgery, Heilongjiang Provincial Hospital, Harbin, Heilongjiang, China.
Yongwang HuangDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Hospital of Tianjin Medical University, Tianjin, China.
Xinchun MaDepartment of Otorhinolaryngology, Head and Neck Surgery, The Affiliated Hospital of Qinghai University, Xining, Qinghai, China.
Zhijun LiuDepartment of Otorhinolaryngology, Head and Neck Surgery, Chizhou People's Hospital, Chizhou, Anhui, China.
Gengtian LiangDepartment of Otorhinolaryngology, Head and Neck Surgery, Wuhan Third Hospital, Wuhan, Hubei, China.
Jian HeDepartment of Otorhinolaryngology, Head and Neck Surgery, Gansu Provincial Hospital, Lanzhou, Gansu, China.
Hua ZhaoDepartment of Otorhinolaryngology Head and Neck Surgery, Xinjiang Military Command General Hospital, Urumqi, Xinjiang, China.
Bailong SongDepartment of Otorhinolaryngology, Head and Neck Surgery, Affiliated Hospital of Chifeng College, Chifeng, Inner Mongolia, China.
Meijun ChenDepartment of Otorhinolaryngology Head and Neck Surgery, The People's Hospital of Dazu District, Chongqing, China.
Xiangli YangDepartment of Otorhinolaryngology Head and Neck Surgery, Tianjin Union Medical Center, Tianjin, China.
Zuopeng MaDepartment of Otorhinolaryngology Head and Neck Surgery, Qinghai Red Cross Hospital, Xining, Qinghai, China.
Jinlong RenDepartment of Otorhinolaryngology, Head and Neck Surgery, Fenyang Hospital, Shanxi Province, Fenyang, Shanxi, China.
Chinese PLA General Hospital · CNPeking University · CNNanchang University · CNCentral South University · CNChizhou University · CNFirst People's Hospital of Chongqing · CNHarbin Medical University · CNHebei Medical University · CNSun Yat-sen University · CNAffiliated Hospital of Southwest Medical University · CNAnhui Medical University · CNBethune International Peace Hospital · CNCapital Medical University · CNChangsha Central Hospital · CNChifeng University · CNChina-Japan Friendship Hospital · CNChongqing Dazu District People's Hospital · CNDalian Municipal Central Hospital · CNFirst Affiliated Hospital of Xiamen University · CNFirst Hospital of China Medical University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeUsing the Reflux Symptom Index (RSI), this nationwide study aimed to investigate the incidence, diagnostic status, risk factors, and common symptoms of adult laryngopharyngeal reflux disease (LPRD) at otorhinolaryngology-head and neck surgery (OHNS) clinics in China.
methodsThis multicenter cross-sectional survey began at the different institutions ranged from July to October 2017, and the duration was 12 months. A total of 90,440 eligible patients were finally enrolled from 72 medical institutions in China. All these patients completed the questionnaire based on RSI. In this study, LPRD was defined as RSI > 13.
resultsThere were 9182 with LPRD among the 90,440 eligible participants (10.15%). However, only 1294 had a history of LPRD diagnosis among those with LPRD (14.09%). There were regional differences in the frequency of LPRD (P < 0.001). The proportions of patients with LPRD in males (vs. females), middle- and old-aged patients (vs. young), with current smoking history (vs. no smoking), and current drinking history (vs. no drinking) were significantly higher (all P < 0.001). Middle and old age, current smoking, and drinking history were independent predictors of LPRD (all P < 0.001, OR 1.240, 1.261, and 1.481, respectively). "Sensations of something stuck in throat or a lump in throat", "clearing throat", and "excess throat mucus or postnasal drip" were the most frequent clinical symptoms in patients with LPRD.
conclusionsLPRD has a high incidence at the OHNS clinics in China. However, the diagnostic status of this disease is not optimistic. Older age, smoking, and drinking history were risk factors for LPRD.
Indexed as
Laryngopharyngeal RefluxOtolaryngologyAdultAgedChinaCross-Sectional StudiesFemaleHumansMaleMiddle AgedSurveys and QuestionnairesCross-sectional surveyLaryngopharyngeal refluxMulti-centerOtorhinolaryngology
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