Evidence map›Paper›PMID 32448943›Full record

ArticlePsychopharmacology2020

Menthol blunts the interoceptive discriminative stimulus effects of nicotine in female but not male rats.

Y Wendy Huynh, Anthony Raimondi, Andrew Finkner, Jordan D Kuck, Carly Selleck, Rick A Bevins

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Cigarette Smoke Extract and Nicotine Evoke Similar Interoceptive Effects in a Pavlovian Occasion Setting Task in Male and Female Sprague-Dawley Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Y Wendy HuynhDepartment of Psychology, University of Nebraska-Lincoln, 238 Burnett Hall, Lincoln, NE, 68588-0308, USA.
Anthony RaimondiDepartment of Psychology, University of Nebraska-Lincoln, 238 Burnett Hall, Lincoln, NE, 68588-0308, USA.
Andrew FinknerDepartment of Psychology, University of Nebraska-Lincoln, 238 Burnett Hall, Lincoln, NE, 68588-0308, USA.
Jordan D KuckDepartment of Psychology, University of Nebraska-Lincoln, 238 Burnett Hall, Lincoln, NE, 68588-0308, USA.
Carly SelleckDepartment of Psychology, University of Nebraska-Lincoln, 238 Burnett Hall, Lincoln, NE, 68588-0308, USA.
Rick A BevinsDepartment of Psychology, University of Nebraska-Lincoln, 238 Burnett Hall, Lincoln, NE, 68588-0308, USA. rbevins1@unl.edu.ORCID http://orcid.org/0000-0002-2438-2264
University of Nebraska–Lincoln · US

Funding

Testing the Efficacy of Ibudilast to Attenuate Meth-seeking and Associated Synaptic Inflammation at the Synapse (TEAMS)P20GM130461 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI KIMBERLY A TYLER · 2019 to 2026
$20.6M
Interoceptive conditioning with nicotine: Changes in abuse liabilityR01DA046109 · NIDA · UNIVERSITY OF NEBRASKA LINCOLN · PI BEVINS, RICK A · 2018 to 2022
$1.8M
Pharmacological interventions to diminish nicotine associated respondingR01DA034389 · NIDA · UNIVERSITY OF NEBRASKA LINCOLN · PI BEVINS, RICK A · 2012 to 2016
$1.4M
NIDA NIH HHS R01 DA034389NIDA NIH HHS R01 DA046109NIGMS NIH HHS P20 GM130461NIH HHS R01-DA034389NIH HHS R01-DA046109
6 · The paper itself

Abstract

rationaleMenthol is a widely used tobacco constituent that has shown to enhance nicotine's reinforcing effects.

objectiveTo determine whether injected menthol also alters nicotine's stimulus effects, we used a drug discrimination task.

methodsA total of 57 adult Sprague-Dawley rats (28M, 29F) received 20 positive and 20 negative days (intermixed) of discrimination training. On positive days, rats received a group-specific menthol and nicotine injection (VEH + 0.1 NIC, 1 M + 0.1 NIC, 5 M + 0.1 NIC, VEH + 0.4 NIC, 1 M + 0.4 NIC, 5 M + 0.4 NIC; mg/kg) before eight 15-s cue light presentations (conditioned stimulus (CS)), each followed by 4-s sucrose access. On negative days, all rats were injected with vehicle and saline before eight non-reinforced CS presentations. Next, rats underwent generalization testing with 30 dose combinations of menthol and nicotine. The change in drug-mediated anticipatory goal tracking during the CS was calculated as a difference score (CS minus pre-CS responding).

resultsAll groups readily acquired drug discrimination. However, difference scores for the 5M + 0.1 NIC group were lower for females. Additionally, females had lower scores for 0.05, 0.1, and 0.4 mg/kg nicotine generalization tests. The lowest nicotine dose discriminable from saline was 0.05 mg/kg for females but 0.025 mg/kg for males. Co-administration with 5 or 10 mg/kg menthol weakened discrimination performance between 0.1 and 0.4 mg/kg and between 0.1 and 0.05 mg/kg nicotine for 0.1 mg/kg nicotine training groups.

conclusionsFemale rats that were trained with 0.1 mg/kg nicotine were more sensitive to menthol's modulatory effects on nicotine's stimulus effects. This highlights the importance of taking sex and training dose into account when evaluating the interoceptive stimulus effects of nicotine and menthol.

Indexed as

Reinforcement, PsychologySex CharacteristicsAnimalsConditioning, OperantDiscrimination LearningDose-Response Relationship, DrugFemaleMaleMentholNicotineRatsRats, Sprague-DawleySucroseMentholNicotineSucroseDrug discriminationMentholNicotineOccasion setterRatsReinforcement learningSex differencesTobacco

Identifiers

PMID32448943
PMCPMC7354904
OpenAlexW3027931358

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.