Evidence map›Paper›PMID 32448677›Full record

Trial reportSchizophrenia research2020

Auditory versus visual neuroscience-informed cognitive training in schizophrenia: Effects on cognition, symptoms and quality of life.

Linda Scoriels, Larissa T Genaro, Luana G C Mororó, Stella Keffer, Anna Luiza D V Guimarães, Paulo V S Ribeiro, Filippe M Tannos, Caroline Novaes, Aniela I França, Nelson Goldenstein and 5 more

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Schizophrenia research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Linda ScorielsInstituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil; Department of Psychiatry, University of Cambridge, United Kingdom.
Larissa T GenaroInstituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil.
Luana G C MororóInstituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil.
Stella KefferInstituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil.
Anna Luiza D V GuimarãesInstituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil.
Paulo V S RibeiroInstituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil.
Filippe M TannosInstituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil.
Caroline NovaesInstituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil.
Aniela I FrançaFaculdade de Letras, Universidade Federal do Rio de Janeiro, Brazil.
Nelson GoldensteinInstituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil.
Barbara J SahakianDepartment of Psychiatry, University of Cambridge, United Kingdom.
Maria T CavalcantiInstituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil.
Melissa FisherDepartment of Psychiatry, University of Minnesota, United States.
Sophia VinogradovDepartment of Psychiatry, University of Minnesota, United States.
Rogerio PanizzuttiInstituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil. Electronic address: rogerio@icb.ufrj.br.
Universidade Federal do Rio de Janeiro · BRUniversity of Minnesota · USUniversity of Cambridge · GB

Funding

Computerized cognitive training for schizophrenia in Brazil.R03TW009002 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PANIZZUTTI, ROGERIO, VINOGRADOV, SOPHIA · 2013 to 2015
$176k
Brain-Plasticity Based Training for SchizophreniaR42MH073358 · NIMH · POSIT SCIENCE CORPORATION · PI MERZENICH, MICHAEL · 2005 to 2005
$140k
FIC NIH HHS R03 TW009002NIMH NIH HHS R42 MH073358
6 · The paper itself

Abstract

backgroundCognitive impairments are related to deficits in primary auditory and visual sensory processes in schizophrenia. These impairments can be remediated by neuroscience-informed computerized cognitive trainings that target auditory and visual processes. However, it is not clear which modality results in greater improvements in cognition, symptoms and quality of life. We aimed to investigate the impact of training auditory versus visual cognitive processes in global cognition in patients with schizophrenia.

methodsSeventy-nine schizophrenia participants were randomly assigned to either 40 h of auditory or visual computerized training. Auditory and visual exercises were chosen to be dynamically equivalent and difficulties increased progressively during the training. We evaluated cognition, symptoms and quality of life before, after 20 h, and after 40 h of training. ClinicalTrials.gov (1R03TW009002-01).

resultsParticipants who received the visual training showed significant improvements in global cognition compared to the auditory training group. The visual training significantly improved attention and reasoning and problem-solving, while the auditory training improved reasoning and problem-solving only. Schizophrenia symptoms improved after training in both groups, whereas quality of life remained unchanged. Interestingly, there was a significant and positive correlation between improvements in attention and symptoms in the visual training group.

conclusionsWe conclude that the visual training and the auditory training are differentially efficient at remediating cognitive deficits and symptoms of clinically stable schizophrenia patients. Ongoing follow-up of participants will evaluate the durability of training effects on cognition and symptoms, as well as the potential impact on quality of life over time.

Indexed as

Cognition DisordersSchizophreniaCognitionHumansQuality of LifeVerbal LearningAuditory trainingCognitive trainingComputerized trainingNeuroplasticitySchizophreniaVisual training

Identifiers

PMID32448677
PMCPMC9703880
OpenAlexW3026349760

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.