Evidence map›Paper›PMID 32448379›Full record

ArticleBMC research notes2020

Weight-for-age distributions among children with HIV on antiretroviral therapy in the International epidemiology Databases to Evaluate AIDS (IeDEA) multiregional consortium.

Julie Jesson, Sophie Desmonde, Constantin T Yiannoutsos, Gabriela Patten, Karen Malateste, Stephany N Duda, Nagalingeswaran Kumarasamy, Marcel Yotebieng, Mary-Ann Davies, Beverly Musick and 3 more

Abstract read
In one paragraph

Article in BMC research notes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Julie JessonInserm U1027, Université Paul Sabatier Toulouse 3, Toulouse, France. julie_jesson@sfu.ca.ORCID http://orcid.org/0000-0002-9461-2520
Sophie DesmondeInserm U1027, Université Paul Sabatier Toulouse 3, Toulouse, France.
Constantin T YiannoutsosIndiana University, Fairbanks School of Public Health, Indianapolis, IN, USA.
Gabriela PattenSchool of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Karen MalatesteInserm U1219, Bordeaux, France.
Stephany N DudaVanderbilt University Medical Center, Nashville, TN, USA.
Nagalingeswaran KumarasamyChennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India.
Marcel YotebiengDivision of Epidemiology, The Ohio State University, College of Public Health, Columbus, OH, USA.
Mary-Ann DaviesSchool of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Beverly MusickIndiana University School of Medicine, Indianapolis, IN, USA.
Valeriane LeroyInserm U1027, Université Paul Sabatier Toulouse 3, Toulouse, France.
Andrea CiaranelloThe Medical Practice Evaluation Center, Boston, MA, USA.
IeDEA

Funding

East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional ConsortiumU01AI069911 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Leslie Anne Enane, AGGREY SEMWENDERO SEMEERE · 2006 to 2026
$57.7M
Observational Antiretroviral Studies In Southern Africa (OASIS) CollaborationU01AI069924 · NIAID · UNIVERSITAT BERN · PI Cleophas Chimbetete, Mary-Ann Davies · 2006 to 2026
$55.9M
The Asia-Pacific HIV Research CollaborationU01AI069907 · NIAID · FOUNDATION FOR AIDS RESEARCH · PI ANNETTE H SOHN · 2006 to 2026
$44.8M
CCASAnet: Caribbean, Central and South America NetworkU01AI069923 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Pedro Enrique Cahn, Jessica L Castilho · 2006 to 2026
$41.6M
"Enhancing Cancer Research in Central Africa IeDEA"U01AI096299 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Denis Nash, Marcel Yotebieng · 2011 to 2026
$35.8M
WADA (West Africa Database on Antiretroviral Therapy) CollaborationU01AI069919 · NIAID · UNIVERSITY OF BORDEAUX II · PI Didier Koumavi Ekouevi, Antoine Jaquet · 2006 to 2026
$29.9M
Harmonist: A Scalable Toolkit for Standardizing and Coordinating Data Sharing Across International Research NetworksR24AI124872 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Stephany Norah Duda · 2016 to 2026
$12.5M
Innovation across the spectrum of pediatric HIV care: Clinical impact and cost-effectiveness of long-acting antiretroviral therapy for breastfeeding people with HIV and their infants in ZimbabweR01HD079214 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI CIARANELLO, ANDREA LYNNE · 2014 to 2023
$8.0M
NIAID NIH HHS R24 AI124872NIAID NIH HHS U01 AI069907NIAID NIH HHS U01 AI069911NIAID NIH HHS U01 AI069919NIAID NIH HHS U01 AI069923NIAID NIH HHS U01 AI069924NIAID NIH HHS U01 AI096299NICHD NIH HHS R01 HD079214NIH HHS U01AI069907NIH HHS U01AI069911NIH HHS U01AI069919NIH HHS U01AI069923NIH HHS U01AI069924NIH HHS U01AI096299
6 · The paper itself

Abstract

objectivePediatric antiretroviral therapy (ART) for children with HIV (CHIV) must be dosed appropriately for children's changing weights as they grow. To inform accurate estimates of ART formulations and doses needed, we described weight-for-age distributions among CHIV on ART in the IeDEA global pediatric collaboration between 2004 and 2016, using data from six regions (East, West, Central, and Southern Africa, Asia-Pacific, and Central/South America and the Caribbean).

resultsOverall, 59,862 children contributed to the analysis. Age and weight data were available from 530,080 clinical encounters for girls and 537,894 for boys. For each one-year age stratum from 0 to 15 years, we calculated the proportion of children in each of the weight bands designated by the World Health Organization as relevant to pediatric ART formulations: 0 to  < 3 kg, 3 to  < 6 kg, 6 to  < 10 kg, 10 to  < 14 kg, 14 to  < 20 kg, 20 to  < 25 kg, 25 to  < 30 kg, 30 to  < 35 kg, 35 to  < 40 kg, 40 to  < 45 kg, 45 to  < 50 kg, 50 to  < 55 kg, 55 to  < 60 kg, and ≥ 60 kg. Data are reported for the entire cohort, as well as stratified by sex and IeDEA region, calendar year of ART use, and duration on ART at time of assessment (< 12 or ≥ 12 months), provided in data tables. These data are critical to improve the accuracy of forecasting and procurement of pediatric ART formulations as the pediatric HIV epidemic and pediatric HIV treatment strategies evolve.

Indexed as

Acquired Immunodeficiency SyndromeAdolescentAfrica, CentralAfrica, EasternAfrica, SouthernAge DistributionAnti-HIV AgentsAsia, SoutheasternCaribbean RegionCentral AmericaChildChild, PreschoolCohort StudiesDatabases, FactualFemaleHIV InfectionsAnti-HIV AgentsAntiretroviral formulationPediatric antiretroviral therapyPediatric HIVWeight-for-age

Identifiers

PMID32448379
PMCPMC7245795

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.