Evidence map›Paper›PMID 32448377›Full record

ReviewStem cell research & therapy2020

Stem cell therapy: a potential approach for treatment of influenza virus and coronavirus-induced acute lung injury.

Jiang Du, Han Li, Jie Lian, Xinxing Zhu, Liang Qiao, Juntang Lin

Open access · goldAbstract readReview
In one paragraph

Review in Stem cell research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Cell therapies for viral diseases: a new frontier.Seminars in immunopathology · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Stem cell therapy for COVID-19 pneumonia.Molecular biomedicine · 2022
    Review
  19. MSCs vs. iPSCs: Potential in therapeutic applications.Frontiers in cell and developmental biology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jiang DuCollege of Biomedical Engineering, Xinxiang Medical University, Xinxiang, 453003, China.
Han LiStem Cell and Biotherapy Engineering Research Center of Henan, Xinxiang Medical University, East of JinSui Road #601, Xinxiang City, Xinxiang, 453003, Henan Province, China.
Jie LianStem Cell and Biotherapy Engineering Research Center of Henan, Xinxiang Medical University, East of JinSui Road #601, Xinxiang City, Xinxiang, 453003, Henan Province, China.
Xinxing ZhuCollege of Biomedical Engineering, Xinxiang Medical University, Xinxiang, 453003, China.
Liang QiaoStem Cell and Biotherapy Engineering Research Center of Henan, Xinxiang Medical University, East of JinSui Road #601, Xinxiang City, Xinxiang, 453003, Henan Province, China.
Juntang LinCollege of Biomedical Engineering, Xinxiang Medical University, Xinxiang, 453003, China. linjtlin@126.com.
Xinxiang Medical University · CN

Funding

Department of Science and Technology of Henan Province 19IRTSTHN003Department of Science and Technology of Henan Province 201100311200Guangzhou Research Collaborative Innovation Projects (CN) 20GG001, 20172DCG-03National Natural Science Foundation of China 81771226
6 · The paper itself

Abstract

Acute lung injury (ALI), an increasingly devastating human disorder, is characterized by a multitude of lung changes arising from a wide variety of lung injuries. Viral infection is the main cause of morbidity and mortality in ALI and acute respiratory distress syndrome (ARDS) patients. In particular, influenza virus, coronavirus, and other respiratory viruses circulate in nature in various animal species and can cause severe and rapidly spread human infections. Although scientific advancements have allowed for rapid progress to be made to understand the pathogenesis and develop therapeutics after each viral pandemic, few effective methods to treat virus-induced ALI have been described. Recently, stem cell therapy has been widely used in the treatment of various diseases, including ALI. In this review, we detail the present stem cell-based therapeutics for lung injury caused by influenza virus and the outlook for the future state of stem cell therapy to deal with emerging influenza and coronaviruses.

Indexed as

Stem Cell TransplantationAcute Lung InjuryBetacoronavirusCell- and Tissue-Based TherapyCoronavirusCytokinesHumansMesenchymal Stem CellsOrthomyxoviridaeSARS-CoV-2CytokinesAcute lung injuryCoronavirusesInfluenza virusLung stem/progenitor cellsMesenchymal stem cellsStem cell therapy

Identifiers

PMID32448377
PMCPMC7245626
OpenAlexW3026490988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.