ArticleInfectious diseases of poverty2020
Disability progression among leprosy patients released from treatment: a survival analysis.
Article in Infectious diseases of poverty, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Experiences of living with leprosy: A systematic review and qualitative evidence synthesis.PLoS neglected tropical diseases · 2022Pooled it
- Systematic Review of Survival Analysis in Leprosy Studies-Including the Following Outcomes: Relapse, Impairment of Nerve Function, Reactions and Physical Disability.International journal of environmental research and public health · 2022Pooled it
- Outcomes of alternative therapy in HLA-B* 13:01 positive leprosy patients without dapsone versus standard MDT in negative patients: A comparative effectiveness study.PLoS neglected tropical diseases · 2026Article
- Associated Factors of Mycobacterium Leprae Infection among People with Leprosy in Kwale County.PLoS neglected tropical diseases · 2025Article
- Relevance of reporting leprosy related disability at the completion of multi drug therapy: A 5-year retrospective analysis of disability in persons affected by leprosy at ALERT Hospital Ethiopia.PLoS neglected tropical diseases · 2024Article
- Progression of the leprosy reaction and nerve damage: A prospective cohort study in children with leprosy from the Brazilian Amazon.PLoS neglected tropical diseases · 2024Article
- Clinical and radiological evaluation of maxillofacial and otorhinolaryngological manifestations of Hansen's disease.Scientific reports · 2022Article
- Functional activity limitation of leprosy cases in an endemic area in Indonesia and recommendations for integrated participation program in society.PLoS neglected tropical diseases · 2022Article
- Peripheral neuropathy in leprosy: Clinical manifestations and disability in a Colombian national referral center.Dermatology reports · 2022Article
- Perception of cure among leprosy patients post completion of multi-drug therapy.BMC infectious diseases · 2021Article
- Risk Factors for Disability Upgrading Among Leprosy Patients During Treatment: Multilevel Modeling Analysis.SAGE open nursingArticle
- Dermlep Study Part 3: Post-RFT Events in Leprosy Patients Presenting to Dermatologists.Indian dermatology online journalArticle
- A review of nutrition in neuropathic pain of leprosy.Therapeutic advances in infectious diseaseReview
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4 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundLeprosy can be cured, but physical disability (PD) as a result of the infection can progress in the post-release from treatment phase. This study evaluated the likelihood of, and factors associated with, the progression of the PD grade post-release from treatment among leprosy patients treated in Cáceres-MT, Brazil in the period 2000 to 2017.
methodsA retrospective cohort study and survival analysis were performed in the hyperendemic municipality of Cáceres in the state of Mato Grosso. The study population consisted of newly diagnosed leprosy patients released from treatment between January 1, 2000 and December 31, 2017. The main outcome was the progression of the PD grade with regard to probability and time; and the evaluated covariates included clinical, operational and demographic variables. The Cox proportional risk model was used to estimate the risk ratio (Hazard Ratios) of the covariates. Both an univariate and a multivariate analysis were implemented, with 95% confidence intervals.
resultsThe mean time for progression of the PD grade was 162 months for PB and 151 months for MB leprosy patients. The survival curve showed that 15 years after the release from treatment, the probability of PD grade progression was 35%, with no difference between PB and MB or age groups. Leprosy reactions and registered medical complaints of any kind during treatment were identified as risk factors with Hazard Ratios of 1.6 and 1.8 respectively.
conclusionsPeople released from treatment as cured of leprosy are susceptible to worsening of the PD, especially those who have had complications during multi-drug therapy treatment. This indicates that leprosy patients should be periodically monitored, even after the successful completion of multidrug therapy.
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