ArticleBMC complementary medicine and therapies2020
Anti-inflammatory and cytotoxic evaluation of extracts from the flowering stage of Celosia argentea.
Article in BMC complementary medicine and therapies, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Metabolites Evaluation, Cytotoxicity, and Teratogenicity Analysis of Selected Medicinal Plants.Scientifica · 2025Article
- Anadenanthera colubrina regulated LPS-induced inflammation by suppressing NF-κB and p38-MAPK signaling pathways.Scientific reports · 2024Article
- Antibacterial Activity and Proposed Mode of Action of Extracts from Selected Zimbabwean Medicinal Plants againstAdvances in pharmacological and pharmaceutical sciences · 2024Article
- Targeting Nrf2 and NF-κB Signaling Pathways in Inflammatory Pain: The Role of Polyphenols from Thinned Apples.Molecules (Basel, Switzerland) · 2023Article
- Ultraviolet Radiation Protective and Anti-Inflammatory Effects ofGels (Basel, Switzerland) · 2022Article
- Toxicological profile, phytochemical analysis and anti-inflammatory properties of leaves ofHeliyon · 2022Article
- Anti-Inflammatory Potential of the Oleoresin from the Amazonian TreeVeterinary sciences · 2021Article
- Cashew (Antioxidants (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThis study was aimed at investigating the possible anti-inflammatory and cytotoxic effects of extracts from the flowering stage of C. argentea. This growth stage was chosen because of its high polyphenolic content and high antioxidant capacity.
methodsAnti-inflammatory potential of the aqueous, acetone and methanol extracts of C. argentea was evaluated through the inhibition of nitric oxide production (LPS-induced) on stimulated macrophages (RAW 264.7), while MTT assay was used to assess cell viability with Silymarin as standard. Cytotoxicity of the plant extracts was evaluated on murine preadipocyte cell line (3 T3-L1) using the image-based method of two DNA-binding dyes; Hoechst 33342 and propidium iodide (PI) with melphalan as standard.
resultsAcetone extract exhibited moderate, dose-dependent anti-inflammatory activity with no significant toxicity to activated macrophages, however the aqueous and methanol extracts were unable to inhibit nitric oxide production at both trials. MTT assay and the toxicity assay revealed that the flowering stage extracts of C. argentea were not toxic to the RAW 264.7 macrophages and 3 T3-L1 cells at all the tested concentrations (0, 2, 50, 100 and 200 μg/mL).
conclusionsThese findings corroborate the traditional use of C. argentea for painful inflammatory conditions and encourage its possible use as lead for the development of novel, non-toxic, anti-inflammatory agents.
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