Evidence map›Paper›PMID 32448310›Full record

ArticleMalaria journal2020

Prevalence and clinical impact of malaria infections detected with a highly sensitive HRP2 rapid diagnostic test in Beninese pregnant women.

Valérie Briand, Gilles Cottrell, Nicaise Tuike Ndam, Xavier Martiáñez-Vendrell, Bertin Vianou, Atika Mama, Bienvenue Kouwaye, Sandrine Houzé, Justine Bailly, Erasme Gbaguidi and 6 more

Erratum issued Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05757167 (Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity), which is not on this map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05757167 phase4active not recruitingnot on this mapstarted 2023, after this paper: background citation

Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity

TypeinterventionalSponsorDuke UniversityRan2023 to 2026Enrolled2,174ConditionsMalaria,Falciparum, Malaria in Pregnancy, Malaria in Childbirth, PregnancyArmsMalaria High-Sensitivity Rapid Diagnostic Test (HS-RDT), Artemether-lumefantrine (AL)
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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  8. Malaria diagnosis challenges andPathogens and global health · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 5 countries.

Valérie BriandInstitut de Recherche Pour le Développement (IRD), University of Bordeaux, Inserm, UMR 1219, 146 rue Léo-Saignat, 33076, Bordeaux Cedex, France. valerie.briand@ird.fr.ORCID https://orcid.org/0000-0001-7927-1855
Gilles CottrellUniversité de Paris, MERIT, IRD, 75006, Paris, France.
Nicaise Tuike NdamUniversité de Paris, MERIT, IRD, 75006, Paris, France.
Xavier Martiáñez-VendrellISGlobal, Hospital Clínic of Barcelona, Universitat de Barcelona, Barcelona, 08036, Spain.
Bertin VianouInstitut de Recherche Clinique du Bénin (IRCB), Cotonou, Benin.
Atika MamaInstitut de Recherche Clinique du Bénin (IRCB), Cotonou, Benin.
Bienvenue KouwayeInstitut de Recherche Clinique du Bénin (IRCB), Cotonou, Benin.
Sandrine HouzéUniversité de Paris, MERIT, IRD, 75006, Paris, France.
Justine BaillyAP-HP, Centre National de Référence sur le paludisme, hôpital Bichat-Claude-Bernard, 75017, Paris, France.
Erasme GbaguidiInstitut de Recherche Clinique du Bénin (IRCB), Cotonou, Benin.
Darius SossouInstitut de Recherche Clinique du Bénin (IRCB), Cotonou, Benin.
Achille MassougbodjiInstitut de Recherche Clinique du Bénin (IRCB), Cotonou, Benin.
Manfred AccrombessiInstitut de Recherche Clinique du Bénin (IRCB), Cotonou, Benin.
Alfredo MayorISGlobal, Hospital Clínic of Barcelona, Universitat de Barcelona, Barcelona, 08036, Spain.
Xavier C DingFIND, 1202, Geneva, Switzerland.
Nadine FievetUniversité de Paris, MERIT, IRD, 75006, Paris, France.
Institut National des Recherches Agricoles du Bénin · BJUniversité Paris Cité · FRBarcelona Institute for Global Health · ESAssistance Publique – Hôpitaux de Paris · FRFIND · CHUniversité de Bordeaux · FRUniversity of London · GB

Funding

Agence Nationale de la Recherche ANR-13-JSV1-0004Bill and Melinda Gates Foundation OPP1169555Fondation Simone Beer 00074147
6 · The paper itself

Abstract

backgroundWhile sub-microscopic malarial infections are frequent and potentially deleterious during pregnancy, routine molecular detection is still not feasible. This study aimed to assess the performance of a Histidine Rich Protein 2 (HRP2)-based ultrasensitive rapid diagnostic test (uRDT, Alere Malaria Ag Pf) for the detection of infections of low parasite density in pregnant women.

methodsThis was a retrospective study based on samples collected in Benin from 2014 to 2017. A total of 942 whole blood samples collected in 327 women in the 1st and 3rd trimesters and at delivery were tested by uRDT, conventional RDT (cRDT, SD BIOLINE Malaria Ag Pf), microscopy, quantitative polymerase chain-reaction (qPCR) and Luminex-based suspension array technology targeting P. falciparum HRP2. The performance of each RDT was evaluated using qPCR as reference standard. The association between infections detected by uRDT, but not by cRDT, with poor maternal and birth outcomes was assessed using multivariate regression models.

resultsThe overall positivity rate detected by cRDT, uRDT, and qPCR was 11.6% (109/942), 16.2% (153/942) and 18.3% (172/942), respectively. Out of 172 qPCR-positive samples, 68 were uRDT-negative. uRDT had a significantly better sensitivity (60.5% [52.7-67.8]) than cRDT (44.2% [36.6-51.9]) and a marginally decreased specificity (93.6% [91.7-95.3] versus 95.7% [94.0-97.0]). The gain in sensitivity was particularly high (33%) and statistically significant in the 1st trimester. Only 28 (41%) out of the 68 samples which were qPCR-positive, but uRDT-negative had detectable but very low levels of HRP2 (191 ng/mL). Infections that were detected by uRDT but not by cRDT were associated with a 3.4-times (95%CI 1.29-9.19) increased risk of anaemia during pregnancy.

conclusionsThis study demonstrates the higher performance of uRDT, as compared to cRDTs, to detect low parasite density P. falciparum infections during pregnancy, particularly in the 1st trimester. uRDT allowed the detection of infections associated with maternal anaemia.

Indexed as

AdultAntigens, ProtozoanDiagnostic Tests, RoutineFemaleHumansMalaria, FalciparumPlasmodium falciparumPregnancyPrevalenceProtozoan ProteinsRetrospective StudiesSensitivity and SpecificityYoung AdultAntigens, ProtozoanHRP-2 antigen, Plasmodium falciparumProtozoan ProteinsAfricaDiagnostic testsHRP-2 antigenMalariaPregnancy

Identifiers

PMID32448310
PMCPMC7247134
OpenAlexW3026216888

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.