ArticleBMC microbiology2020
Profiles of Staphyloccocus aureus isolated from goat persistent mastitis before and after treatment with enrofloxacin.
Article in BMC microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- A comprehensive study on enrofloxacin residue depletion in five chicken breeds.Poultry science · 2026Article
- Ecological Dynamics ofAntibiotics (Basel, Switzerland) · 2026Article
- Sensitivity profile of tolerant and persistent Staphylococcus spp. from goat mastitis to Jatobá (Hymenaea martiana Hayne) extract.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Methicillin-ResistantMicroorganisms · 2026Review
- Nonantibiotic Alternatives for Mastitis in Small Ruminants: A Scoping Review of Evidence, Gaps, and Translational Challenges.Veterinary medicine international · 2026Review
- Fingerprinting PCR Reveals Potential Dissemination of Multidrug Efflux System Genes and Antimicrobial Resistance inInternational journal of microbiology · 2026Article
- Multidrug Efflux System-mediated resistance in Staphylococcus aureus under a One Health approach.World journal of microbiology & biotechnology · 2023Article
- Recent Trends of Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2023Article
- Vancomycin Resistance inMicroorganisms · 2022Review
- Antimicrobial Resistance, Enterotoxin andMicroorganisms · 2022Article
- Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistantEFSA journal. European Food Safety Authority · 2022Article
- Serbian Traditional Goat Cheese: Physico-Chemical, Sensory, Hygienic and Safety Characteristics.Microorganisms · 2021Article
- Multilocus sequence analysis reveals genetic diversity in Staphylococcus aureus isolate of goat with mastitis persistent after treatment with enrofloxacin.Scientific reports · 2021Article
- Molecular Characterization of Antimicrobial Resistance and Virulence Genes of Bacterial Pathogens from Bovine and Caprine Mastitis in Northern Lebanon.Microorganisms · 2021Article
- Synthesis of Degraded Limonoid Analogs as New Antibacterial Scaffolds againstAntibiotics (Basel, Switzerland) · 2020Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStaphylococcus aureus is one of the main causative agents of mastitis in small ruminants. Antimicrobial use is the major treatment, but there are many flaws linked to resistance, tolerance or persistence. This study aimed to verify changes in resistance, virulence and clonal profiles of S. aureus isolated from persistent mastitis goat milk before and after enrofloxacin treatment.
resultsMIC increased to at least one antimicrobial in S. aureus isolates after enrofloxacin treatment compared to before. The most detected resistance genes before and after treatment were tetK, tetM, and blaZ, with more resistance genes detected after enrofloxacin treatment (p < 0.05). Occasional variations in efflux system gene detection were observed before and after treatment. Nine virulence genes (hla, fnbA, fnbB, eta, etb, sea, sec, seh, and sej) were detected at both times, and between these, the hla and eta genes were detected more in isolates after treatment. All isolates of S. aureus belonged to the same sequence type (ST) 133, except for two S. aureus isolates prior to enrofloxacin treatment which were classified as ST5 and the other as a new one, ST4966. Isolates of S. aureus 4, 8, and 100 from before and after treatment had identical pulse types, while others obtained from other animals before and after treatment were classified into distinct pulse types.
conclusionThere were occasional changes in the studied profiles of S. aureus isolated before and after treatment of animals with enrofloxacin, which may have contributed to the permanence of bacteria in the mammary gland, even when using traditional treatment, resulting in persistent mastitis.
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