ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2020
Parameter subset reduction for patient-specific modelling of arrhythmogenic cardiomyopathy-related mutation carriers in the CircAdapt model.
Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 31 citations in OpenAlex.
- Numerical accuracy of closed-loop steady state in a zero-dimensional cardiovascular model.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Article
- Parameter subset reduction for imaging-based digital twin generation of patients with left ventricular mechanical discoordination.Biomedical engineering online · 2024Article
- How to assess and treat right ventricular electromechanical dyssynchrony in post-repair tetralogy of Fallot: insights from imaging, invasive studies, and computational modelling.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
- Biventricular Interaction During Acute Left Ventricular Ischemia in Mice: A Combined In-Vivo and In-Silico Approach.Annals of biomedical engineering · 2023Article
- A variable heart rate multi-compartmental coupled model of the cardiovascular and respiratory systems.Journal of the Royal Society, Interface · 2023Article
- Biventricular interaction during acute left ventricular ischemia in mice: a combined in-vivo and in-silico approach.bioRxiv : the preprint server for biology · 2023Article
- An in-silico analysis of experimental designs to study ventricular function: A focus on the right ventricle.PLoS computational biology · 2022Article
- Computational models of ventricular mechanics and adaptation in response to right-ventricular pressure overload.Frontiers in physiology · 2022Review
- A Lumped Two-Compartment Model for Simulation of Ventricular Pump and Tissue Mechanics in Ischemic Heart Disease.Frontiers in physiology · 2022Article
- A computationally efficient physiologically comprehensive 3D-0D closed-loop model of the heart and circulation.Computer methods in applied mechanics and engineering · 2021Article
- Electromechanical substrate characterization in arrhythmogenic cardiomyopathy using imaging-based patient-specific computer simulations.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021Article
- Uncertainty Quantification of Regional Cardiac Tissue Properties in Arrhythmogenic Cardiomyopathy Using Adaptive Multiple Importance Sampling.Frontiers in physiology · 2021Article
- The fickle heart: uncertainty quantification in cardiac and cardiovascular modelling and simulation.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arrhythmogenic cardiomyopathy (AC) is an inherited cardiac disease, clinically characterized by life-threatening ventricular arrhythmias and progressive cardiac dysfunction. Patient-specific computational models could help understand the disease progression and may help in clinical decision-making. We propose an inverse modelling approach using the CircAdapt model to estimate patient-specific regional abnormalities in tissue properties in AC subjects. However, the number of parameters (
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