Evidence map›Paper›PMID 32447991›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2020

Ribophorin II is upregulated in myelodysplastic syndromes and prevents apoptosis and cell cycle progression.

Jinhai Ren, Ying Wang, Lihua Wang, Xiaoling Guo, Xiaonan Guo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jinhai RenDepartment of Hematology, Second Hospital of Hebei Medical University, Key Laboratory of Hematology of Hebei Province, Shijiazhuang, Hebei 050000, China.
Ying WangDepartment of Hematology, Second Hospital of Hebei Medical University, Key Laboratory of Hematology of Hebei Province, Shijiazhuang, Hebei 050000, China.
Lihua WangDepartment of Hematology, Second Hospital of Hebei Medical University, Key Laboratory of Hematology of Hebei Province, Shijiazhuang, Hebei 050000, China.
Xiaoling GuoDepartment of Hematology, Second Hospital of Hebei Medical University, Key Laboratory of Hematology of Hebei Province, Shijiazhuang, Hebei 050000, China.
Xiaonan GuoDepartment of Hematology, Second Hospital of Hebei Medical University, Key Laboratory of Hematology of Hebei Province, Shijiazhuang, Hebei 050000, China.ORCID 0000-0001-7269-7685
Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

impact statementThis study explored the role of ribophorin II (RPN2) in myelodysplastic syndromes (MDSs) cell proliferation and growth and revealed that RPN2 knockdown suppressed OCI-AML3 cell growth and proliferation and triggered cell cycle arrest and elicited apoptosis in OCI-AML3 cells. In addition, it shed light on the etiology of RPN2's role in MDS cell proliferation that RPN2 can negatively impact enhancer of zeste homolog-2 (EZH2) expression, which in turn is able to modulate the cell cycle location and death in OCI-AML3 cells. Hence, RPN2 expression could be a latent predictor of prognosis in patients with MDS.

Indexed as

ApoptosisCell Cycle CheckpointsCell Line, TumorCell ProliferationCore Binding Factor Alpha 1 SubunitDown-RegulationEnhancer of Zeste Homolog 2 ProteinGene Expression Regulation, NeoplasticHexosyltransferasesHumansMyelodysplastic SyndromesProteasome Endopeptidase ComplexRNA, MessengerUp-RegulationCore Binding Factor Alpha 1 SubunitEnhancer of Zeste Homolog 2 ProteinHexosyltransferasesProteasome Endopeptidase ComplexRNA, MessengerRPN2 protein, humanapoptosiscell cycleenhancer of zeste homolog-2Myelodysplastic syndromeribophorin II

Identifiers

PMID32447991
PMCPMC7357142
OpenAlexW3026400117

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.