ArticleCephalalgia : an international journal of headache2020
Infectious and inflammatory disorders might increase the risk of developing idiopathic intracranial hypertension - a national case-control study.
Article in Cephalalgia : an international journal of headache, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Migratory Venous Sinus Stenosis After Stenting for Idiopathic Intracranial Hypertension: a Single-Center Case Series.Clinical neuroradiology · 2026Article
- Recurrent crescendo headache and subconjunctival hemorrhage in the setting of intracranial hypertension with IgA nephropathy.Proceedings (Baylor University. Medical Center) · 2026Article
- Association between craniosynostosis and neurodevelopmental disorders: a nationwide claims database.BMC pediatrics · 2026Article
- Inflammation in Idiopathic Intracranial Hypertension: An Immunometabolic Mechanistic Framework and Clinical Implications.CNS neuroscience & therapeutics · 2026Review
- Routine Blood and Cerebrospinal Fluid Markers in Newly Diagnosed Idiopathic Intracranial Hypertension: An Exploratory Case-Control Study.Eye and brain · 2026Article
- Imaging hallmarks of idiopathic intracranial hypertension and insights into pathogenesis.Frontiers in radiology · 2025Review
- Progress and recognition of idiopathic intracranial hypertension: A narrative review.CNS neuroscience & therapeutics · 2024Review
- COVID-19 in the nervous system: physiopathology and neurological manifestations.Arquivos de neuro-psiquiatria · 2023Review
- De Novo Presentation of Idiopathic Intracranial Hypertension (IIH) Associated With COVID-19 Infection.The Neurohospitalist · 2022Article
- A national Swedish case-control study investigating incidence and factors associated with idiopathic intracranial hypertension.Cephalalgia : an international journal of headache · 2021Article
- A wide spectrum of neurological manifestations in pediatrics patients with the COVID-19 infection: a case series.Journal of neurovirology · 2021Article
- Commentary: The role of inflammation in idiopathic intracranial hypertension.Indian journal of ophthalmology · 2021Article
- Risk Estimation of Infectious and Inflammatory Disorders in Hospitalized Patients With Acute Ischemic Stroke Using Clinical-Lab Nomogram.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether conditions causing inflammatory activation are associated with increased risk of idiopathic intracranial hypertension.
methodsAll newly diagnosed idiopathic intracranial hypertension patients (cases) in Sweden between 2000-2016 were identified using pre-determined algorithms (n = 902) and matched with five controls from the general population and five individuals with an obesity diagnosis (n = 4510) for age, sex, region, and vital status. National health registers provided information on infections, inflammatory disorders and dispensed medications. Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals.
resultsCompared to general population controls, the cases had fourfold increased odds of having an infection (odds ratio = 4.3, 95% confidence interval 3.3-5.6), and threefold increased odds of an inflammatory disorder the year prior to idiopathic intracranial hypertension diagnosis (odds ratio = 3.2, 95% confidence interval 2.4-4.3). Organ specific analyses showed that odds were increased for the study diseases in the respiratory organ, kidney organ and gastrointestinal tract, but not for female genital infections. Similar results were found when comparing idiopathic intracranial hypertension with obese controls though the odds ratios were of lower magnitude. Sub-analyses on exposure to anti-infectious and anti-inflammatory drugs confirmed the increased odds ratios for idiopathic intracranial hypertension patients.
conclusionsThese findings suggest that major inflammatory activation may be a risk factor in idiopathic intracranial hypertension development.
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