Evidence map›Paper›PMID 32447643›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2021

The effects of human sera conditioned by high-intensity exercise sessions and training on the tumorigenic potential of cancer cells.

G Baldelli, M De Santi, M Gervasi, G Annibalini, D Sisti, P Højman, P Sestili, V Stocchi, E Barbieri, G Brandi

Erratum issued Registry-linked trialOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06987708 (Evaluating the Impact of a 12-month Multi-Modal Lifestyle Management Intervention on Disease Relevant Biomarkers Associated With Monoclonal Gammopathy of Unknown Significance), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06987708 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluating the Impact of a 12-month Multi-Modal Lifestyle Management Intervention on Disease Relevant Biomarkers Associated With Monoclonal Gammopathy of Unknown Significance (MGUS) and Smoldering Myeloma (SM): A Prospective Intervention Pilot Study

TypeinterventionalSponsorHackensack Meridian HealthRan2026 to 2028Enrolled67ConditionsMonoclonal Gammopathy of Uncertain Significance, Smoldering MyelomaArmsThe Multimodal Lifestyle Intervention
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

G BaldelliPharmacology and Public Health Unit, Biomolecular Sciences Department, University of Urbino Carlo Bo, Urbino, PU, Italy.
M De SantiPharmacology and Public Health Unit, Biomolecular Sciences Department, University of Urbino Carlo Bo, Urbino, PU, Italy. mauro.desanti@uniurb.it.ORCID http://orcid.org/0000-0003-2983-8344
M GervasiExercise and Health Sciences Unit, Biomolecular Sciences Department, University of Urbino Carlo Bo, Urbino, PU, Italy.
G AnnibaliniExercise and Health Sciences Unit, Biomolecular Sciences Department, University of Urbino Carlo Bo, Urbino, PU, Italy.
D SistiService of Biostatistics, Biomolecular Sciences Department, University of Urbino Carlo Bo, Urbino, PU, Italy.
P HøjmanCentre of Inflammation and Metabolism (CIM) and Centre for Physical Activity Research (CFAS), Rigshospitalet, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.
P SestiliExercise and Health Sciences Unit, Biomolecular Sciences Department, University of Urbino Carlo Bo, Urbino, PU, Italy.
V StocchiExercise and Health Sciences Unit, Biomolecular Sciences Department, University of Urbino Carlo Bo, Urbino, PU, Italy.
E BarbieriExercise and Health Sciences Unit, Biomolecular Sciences Department, University of Urbino Carlo Bo, Urbino, PU, Italy.
G BrandiPharmacology and Public Health Unit, Biomolecular Sciences Department, University of Urbino Carlo Bo, Urbino, PU, Italy.
University of Urbino · ITUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThere is growing evidence of an association between physical activity and a reduced risk of cancer and cancer recurrence. The aim of this study was to assess the effects of exercise-conditioned human serum (HS) effects on the proliferative and tumorigenic potential of triple-negative breast cancer (TNBC) and prostate cancer (PC) cells. Moreover, modulated mechanisms and several physiological factors that can predict exercise effects were investigated.

methodsThirty healthy sedentary subjects were recruited for the study. The subjects performed two high-intensity endurance cycling (HIEC) sessions before and after a nine-week period of high-intensity interval training (HIIT). Cell tumorigenic capacity affected by HS collected before (t0), immediately after (t1), 4 h (t2), and 24 h (t3) after the HIEC sessions was evaluated by in vitro three-dimensional colony formation. The modulation of molecular pathways was analyzed by western blotting and qPCR in TNBC and PC cells, and in TNBC xenografts in exercised mice.

resultsAll of the HIEC-conditioned HS (t1, t2, and t3) markedly impacted the proliferative and the microtumor-forming capacity of both TNBC and PC cell lines, while the HS collected from the subjects at rest did not. Modulation of the Hippo and Wnt/β-catenin pathways by HIEC-conditioned HS before and after the period of HIIT was shown. Multiple linear regression analysis showed relationships between the effects of HIEC-conditioned HS in PC cells, lactate threshold and VO

conclusionsThese results highlight the potential of HIEC bouts in tumor progression control and the importance of optimizing an approach to identify physiological predictors of the effects of acute exercise in tertiary cancer prevention.

Indexed as

High-Intensity Interval TrainingAnimalsBicyclingCell Line, TumorCell ProliferationCulture Media, ConditionedDisease ProgressionFemaleGlycogen Synthase Kinase 3 betaHippo Signaling PathwayHumansMaleMiceMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3PhosphorylationCulture Media, ConditionedGlycogen Synthase Kinase 3 betaMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Protein Serine-Threonine KinasesAcute exerciseCancer cell proliferationHigh-intensity endurance cyclingLong-term trainingThree-dimensional cell cultureTumor progression

Identifiers

PMID32447643
OpenAlexW3027007845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.