Evidence map›Paper›PMID 32447602›Full record

ArticleClinical rheumatology2020

Reduction of fat free mass index and phase angle is a risk factor for development digital ulcers in systemic sclerosis patients.

Edoardo Rosato, Antonietta Gigante, Andrea Iacolare, Annalisa Villa, Maria Ludovica Gasperini, Maurizio Muscaritoli

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical rheumatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Edoardo RosatoDepartment of Translational and Precision Medicine-Scleroderma Unit, Sapienza University of Rome, Viale dell'Università 37, 00185, Rome, Italy. edoardo.rosato@uniroma1.it.ORCID https://orcid.org/0000-0002-7417-8093
Antonietta GiganteDepartment of Translational and Precision Medicine-Scleroderma Unit, Sapienza University of Rome, Viale dell'Università 37, 00185, Rome, Italy.
Andrea IacolareDepartment of Translational and Precision Medicine-Scleroderma Unit, Sapienza University of Rome, Viale dell'Università 37, 00185, Rome, Italy.
Annalisa VillaDepartment of Translational and Precision Medicine-Scleroderma Unit, Sapienza University of Rome, Viale dell'Università 37, 00185, Rome, Italy.
Maria Ludovica GasperiniDepartment of Translational and Precision Medicine-Scleroderma Unit, Sapienza University of Rome, Viale dell'Università 37, 00185, Rome, Italy.
Maurizio MuscaritoliDepartment of Translational and Precision Medicine-Scleroderma Unit, Sapienza University of Rome, Viale dell'Università 37, 00185, Rome, Italy.
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION/

objectivesThis study aims to evaluate the role of fat free mass index (FFMI) and phase angle (PhA) as markers to predict occurrence of new digital ulcers in systemic sclerosis (SSc) patients.

methodsBody composition evaluation from bioelectrical impedance and clinical assessment were performed in SSc patients at enrollment and after 12 months follow-up.

resultsSeventy-nine SSc patients (67 female) with a mean age of 53 ± 13 years were enrolled. In SSc patients with a digital ulcers history, FFMI value is lower (p < 0.05) and phase angle (PhA) value is higher (p < 0.01) than SSc patients without a digital ulcers history. After 12 months of follow-up, 30 patients (38%) presented at least one new episode of digital ulcers. Patients with reduced FFMI had a relative risk of 6.7 for new digital ulcers (CI 2.1-21.8, p < 0.001). Patients with reduced PhA had a relative risk of 10.1 for new digital ulcers (CI 3.5-29.5, p < 0.0001). In multivariate analysis, FFMI and PhA were associated with major vascular complication (digital ulcers, pulmonary arterial hypertension, and scleroderma renal crisis). FFMI loss, assessed as delta between follow-up and baseline, is higher in SSc with short duration (≤ 3 years) than SSc patients with long duration [0.4 (0-0.50) vs - 0.10 (- 0.2-0)].

conclusionIn SSc patients, reduction of the FFMI and PhA represents after 12 months a risk factor for development of new digital ulcers and major vascular complication. Key Points • Fat free mass index represents a risk factor for development of digital ulcers • Phase angle represents a risk factor for development of digital ulcers • Body compositions in systemic sclerosis are a marker of activity disease.

Indexed as

Scleroderma, SystemicSkin UlcerAdultAgedFemaleFingersHumansMaleMiddle AgedPulmonary Arterial HypertensionRisk FactorsUlcerBioimpedance analysisBody compositionDigital ulcersPhase angleSarcopeniaSystemic sclerosis

Identifiers

PMID32447602
OpenAlexW3026605260

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.