Evidence map›Paper›PMID 32447449›Full record

ReviewMedical microbiology and immunology2020

Tspan18 is a novel regulator of thrombo-inflammation.

Rebecca L Gavin, Chek Ziu Koo, Michael G Tomlinson

Open access · hybridAbstract readReview
In one paragraph

Review in Medical microbiology and immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Function of Platelet Glycosphingolipid Microdomains/Lipid Rafts.International journal of molecular sciences · 2020
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rebecca L GavinSchool of Biosciences, University of Birmingham, Birmingham, UK.
Chek Ziu KooSchool of Biosciences, University of Birmingham, Birmingham, UK.
Michael G TomlinsonSchool of Biosciences, University of Birmingham, Birmingham, UK. m.g.tomlinson@bham.ac.uk.ORCID http://orcid.org/0000-0002-1189-0091
University of Birmingham · GB

Funding

Biotechnology and Biological Sciences Research Council PhD StudentshipBritish Heart Foundation FS/18/9/33388
6 · The paper itself

Abstract

The interplay between thrombosis and inflammation, termed thrombo-inflammation, causes acute organ damage in diseases such as ischaemic stroke and venous thrombosis. We have recently identified tetraspanin Tspan18 as a novel regulator of thrombo-inflammation. The tetraspanins are a family of 33 membrane proteins in humans that regulate the trafficking, clustering, and membrane diffusion of specific partner proteins. Tspan18 partners with the store-operated Ca

Indexed as

AnimalsBlood PlateletsCalcium SignalingChick EmbryoEmbryonic DevelopmentEndothelial CellsGene Knockdown TechniquesHumansInflammationMiceMice, KnockoutORAI1 ProteinPlatelet Membrane GlycoproteinsTetraspaninsThrombosisORAI1 ProteinORAI1 protein, humanOrai1 protein, mousePlatelet Membrane Glycoproteinsplatelet membrane glycoprotein VITetraspaninsTSPAN18 protein, humanEndothelial cellOrai1PlateletStore-operated Ca2+ entryTetraspaninThrombo-inflammationTspan18

Identifiers

PMID32447449
PMCPMC7395042
OpenAlexW3027335759

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.