Evidence map›Paper›PMID 32447322›Full record

ArticleJournal of medical genetics2021

Hypomethylation of a centromeric block of ICR1 is sufficient to cause Silver-Russell syndrome.

Ken Higashimoto, Hijiri Watanabe, Yuka Tanoue, Hidefumi Tonoki, Tomoharu Tokutomi, Satoshi Hara, Hitomi Yatsuki, Hidenobu Soejima

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ken HigashimotoDivision of Molecular Genetics & Epigenetics, Department of Biomolecular Sciences, Saga University Faculty of Medicine, Saga, Japan soejimah@cc.saga-u.ac.jp higashim@cc.saga-u.ac.jp.
Hijiri WatanabeDepartment of Pediatrics, Amakusa Medical Center, Amakusa, Japan.
Yuka TanoueDivision of Molecular Genetics & Epigenetics, Department of Biomolecular Sciences, Saga University Faculty of Medicine, Saga, Japan.
Hidefumi TonokiMedical Genetics Center, Department of Pediatrics, Tenshi Hospital, Sapporo, Japan.
Tomoharu TokutomiDepartment of Clinical Genetics, School of Medicine, Iwate Medical University, Morioka, Japan.
Satoshi HaraDivision of Molecular Genetics & Epigenetics, Department of Biomolecular Sciences, Saga University Faculty of Medicine, Saga, Japan.
Hitomi YatsukiDivision of Molecular Genetics & Epigenetics, Department of Biomolecular Sciences, Saga University Faculty of Medicine, Saga, Japan.
Hidenobu SoejimaDivision of Molecular Genetics & Epigenetics, Department of Biomolecular Sciences, Saga University Faculty of Medicine, Saga, Japan soejimah@cc.saga-u.ac.jp higashim@cc.saga-u.ac.jp.ORCID 0000-0001-5076-6563
Saga University · JPIwate Medical University · JPTenshi Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Silver-Russell syndrome (SRS) is a representative imprinting disorder. A major cause is the loss of methylation (LOM) of imprinting control region 1 (ICR1) within the

Indexed as

DNA MethylationCatalytic DomainCentromereChildChild, PreschoolFemaleHumansInsulin-Like Growth Factor IIMalePromoter Regions, GeneticRegulatory Sequences, Nucleic AcidSilver-Russell SyndromeTelomereIGF2 protein, humanInsulin-Like Growth Factor IIepigeneticsimprinting

Identifiers

PMID32447322
PMCPMC8142445
OpenAlexW3028076572

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.