Observational studyHeart (British Cardiac Society)2020
Early cardiac magnetic resonance imaging in troponin-positive acute chest pain and non-obstructed coronary arteries.
Observational study in Heart (British Cardiac Society), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05139329 (Observational Registry of Ischemia Negative Chest Pain as the Presentation of Underlying Myocarditis), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Observational Registry of Ischemia Negative Chest Pain as the Presentation of Underlying Myocarditis: the ORCHESTRATE-Myocarditis Registry
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Diagnostic Value of Cardiovascular Magnetic Resonance T1 and T2 Mapping in Acute Myocarditis: A Systematic Literature Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Cardiovascular Magnetic Resonance in MINOCA and Acute Myocarditis: A Comparative Multiparametric Evaluation.The international journal of cardiovascular imaging · 2026Article
- The role of cardiac CT with late iodine enhancement in patients with acute cardiac symptoms and troponin elevation in the era of high-sensitivity assays.European radiology · 2026Article
- High-sensitivity troponin T as a rule-out marker for myocardial inflammation detectable by CMR imaging.Open heart · 2025Article
- Longitudinal Myocardial Deformation as an Emerging Biomarker for Post-Traumatic Cardiac Dysfunction.Life (Basel, Switzerland) · 2025Review
- Prognostic Value of Strain by Tissue Tracking Cardiac Magnetic Resonance in Myocardial Infarction With Nonobstructive Coronary Arteries.Journal of the American Heart Association · 2025Observational
- Cardiac magnetic resonance imaging in myocardial infarction with non-obstructed coronary arteries: diagnostic and prognostic value.American journal of cardiovascular disease · 2025Review
- Ejection Fraction-Related Differences of Baseline Characteristics and Outcomes in Troponin-Positive Patients without Obstructive Coronary Artery Disease.Journal of clinical medicine · 2024Article
- Value of a short non-contrast CMR protocol in MINOCA.European radiology · 2024Article
- Computed tomography coronary angiography in non-ST-segment elevation myocardial infarction.The British journal of radiology · 2022Review
- Subclinical left ventricular systolic function impairment detected in myocardial infarction with nonobstructive coronary arteries (MINOCA): a New Clinical Application Field of Speckle Tracking Echocardiography.The international journal of cardiovascular imaging · 2022Article
- Assessment of Cardiac, Vascular, and Pulmonary Pathobiology In Vivo During Acute COVID-19.Journal of the American Heart Association · 2022Article
- Mechanical dispersion combined with global longitudinal strain estimated by three dimensional speckle tracking in patients with ST elevation myocardial infarction.International journal of cardiology. Heart & vasculature · 2022Article
- Role of Multimodality Imaging in the Assessment of Myocardial Infarction With Nonobstructive Coronary Arteries: Beyond Conventional Coronary Angiography.Journal of the American Heart Association · 2022Review
- The outcome of patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) and impaired kidney function: a 3-year observational study.International urology and nephrology · 2021Observational
- The Bright Side of Myocardial Edema.Journal of the American Heart Association · 2021Article
- A Cost Analysis of Cardiac Magnetic Resonance Imaging in the Diagnostic Pathway of Patients Presenting With Unexplained Acute Myocardial Injury and Culprit-Free Coronary Angiography.Frontiers in cardiovascular medicine · 2021Article
- An unusual case of apical myocarditis: a case report.European heart journal. Case reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe assessed the diagnostic and prognostic implications of early cardiac magnetic resonance (CMR), CMR-based deformation imaging and conventional risk factors in patients with troponin-positive acute chest pain and non-obstructed coronary arteries.
methodsIn total, 255 patients presenting between 2009 and 2019 with troponin-positive acute chest pain and non-obstructed coronary arteries who underwent CMR in ≤7 days were followed for a clinical endpoint of all-cause mortality. Cine movies, T2-weighted and late gadolinium-enhanced images were evaluated to establish a diagnosis of the underlying heart disease. Further CMR analysis, including left ventricular strain, was carried out.
resultsCMR (performed at a mean of 2.7 days) provided the diagnosis in 86% of patients (54% myocarditis, 22% myocardial infarction (MI) and 10% Takotsubo syndrome and myocardial contusion (n=1)). The 4-year mortality for a diagnosis of MI, myocarditis, Takotsubo and normal CMR patients was 10.2%, 1.6%, 27.3% and 0%, respectively. We found a strong association between CMR diagnosis and mortality (log-rank: 24, p<0.0001). Takotsubo and MI as the diagnosis, age, hypertension, diabetes, female sex, ejection fraction, stroke volume index and most of the investigated strain parameters were univariate predictors of mortality; however, in the multivariate analysis, only hypertension and circumferential mechanical dispersion measured by strain analysis were independent predictors of mortality.
conclusionsCMR performed in the early phase establishes the proper diagnosis in patients with troponin-positive acute chest pain and non-obstructed coronary arteries and provides additional prognostic factors. This may indicate that CMR could play an additional role in risk stratification in this patient population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.