Evidence map›Paper›PMID 32447234›Full record

ArticleParkinsonism & related disorders2020

Genetic characterization of Parkinson's disease patients in Ecuador and Colombia.

Philip W Tipton, Gabriela Jaramillo-Koupermann, Alexandra I Soto-Beasley, Ronald L Walton, Silvia Soler-Rangel, Óscar Romero-Osorio, Cindy Díaz, Claudia Lucía Moreno-López, Owen A Ross, Zbigniew K Wszolek and 2 more

Open access · greenAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Rethinking 'rare'Journal of Parkinson's disease · 2025
    Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Philip W TiptonDepartment of Neurology, Mayo Clinic, Mangurian Building, Jacksonville, FL, 32224, USA.
Gabriela Jaramillo-KoupermannDepartment of Pathology, Hospital Eugenio Especjo, Quito, Ecuador.
Alexandra I Soto-BeasleyDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Ronald L WaltonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Silvia Soler-RangelMovement Disorders Clinic, Hospital Universitario San Ignacio, Bogota, Colombia; School of Medicine, Pontificia Universidad Javeriana, Bogota, Colombia.
Óscar Romero-OsorioMovement Disorders Clinic, Hospital Universitario San Ignacio, Bogota, Colombia; School of Medicine, Pontificia Universidad Javeriana, Bogota, Colombia.
Cindy DíazMovement Disorders Clinic, Hospital Universitario San Ignacio, Bogota, Colombia; School of Medicine, Pontificia Universidad Javeriana, Bogota, Colombia.
Claudia Lucía Moreno-LópezMovement Disorders Clinic, Hospital Universitario San Ignacio, Bogota, Colombia; Fundación Cardioinfantil, Bogotá, Colombia.
Owen A RossDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA; Department of Clinical Genomics, Mayo Clinic, Jacksonville, FL, 32224, USA.
Zbigniew K WszolekDepartment of Neurology, Mayo Clinic, Mangurian Building, Jacksonville, FL, 32224, USA. Electronic address: Wszolek.Zbigniew@mayo.edu.
Catalina Cerquera-ClevesMovement Disorders Clinic, Hospital Universitario San Ignacio, Bogota, Colombia; School of Medicine, Pontificia Universidad Javeriana, Bogota, Colombia; Clínica Universitaria Colombia, Bogota, Colombia.
Fernando AlarconDepartment of Neurology, Movement Disorders Unit, Hospital Eugenio Especjo, Quito, Ecuador.
Mayo Clinic in Florida · USPontificia Universidad Javeriana · COHospital Universitario San Ignacio · COHospital Vozandes · EC

Funding

Utilization of proteomics and lipidomics to identify modifiers of LBDU54NS110435 · NINDS · MAYO CLINIC JACKSONVILLE · PI MCLEAN, PAMELA J · 2019 to 2023
$14.5M
Neuropathology CoreP50NS072187 · NINDS · MAYO CLINIC JACKSONVILLE · PI DICKSON, DENNIS WILLIAM · 2010 to 2017
$8.7M
Project 2: Identifying genes and Pathways that impact Tau Toxicity in FTDU54NS100693 · NINDS · MAYO CLINIC JACKSONVILLE · PI DICKSON, DENNIS WILLIAM · 2016 to 2020
$6.2M
Understanding the role of MAPT in Parkinsonian disordersR01NS078086 · NINDS · MAYO CLINIC JACKSONVILLE · PI ROSS, OWEN A · 2012 to 2016
$1.7M
NINDS NIH HHS P50 NS072187NINDS NIH HHS R01 NS078086NINDS NIH HHS U54 NS100693NINDS NIH HHS U54 NS110435
6 · The paper itself

Abstract

To help address the scarcity of studies on the genetics of Parkinson's disease (PD) in Latin America, we screened 426 Ecuadorians with PD and 80 Colombians (PD = 55, Control = 26) for mutations within several PD-related genes. Among Colombians, we identified several variants within PARKIN and PINK1 genes.

Indexed as

AgedAged, 80 and overColombiaEcuadorFemaleHumansMaleMiddle AgedParkinson DiseaseProtein KinasesPTEN-Induced Putative KinaseUbiquitin-Protein Ligasesparkin proteinProtein KinasesPTEN-Induced Putative KinaseUbiquitin-Protein LigasesGeneticsLatin AmericaParkinson's disease

Identifiers

PMID32447234
PMCPMC10236935
OpenAlexW3024165658

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.