Evidence map›Paper›PMID 32447069›Full record

ArticleNuclear medicine and biology

Radiosynthesis, in vitro and preliminary in vivo evaluation of the novel glutamine derived PET tracers [

Tristan Baguet, Jeroen Verhoeven, Glenn Pauwelyn, Jiyun Hu, Patricia Lambe, Stef De Lombaerde, Sarah Piron, Sam Donche, Benedicte Descamps, Ingeborg Goethals and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nuclear medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Recent Advances inPharmaceutics · 2022
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Tristan BaguetLaboratory of Radiopharmacy, Ghent University, Ghent, Belgium. Electronic address: tristan.baguet@ugent.be.
Jeroen VerhoevenLaboratory of Radiopharmacy, Ghent University, Ghent, Belgium.
Glenn PauwelynLaboratory of Radiopharmacy, Ghent University, Ghent, Belgium.
Jiyun HuDepartment of Chemistry and Biochemistry, University of Arkansas, AR, USA.
Patricia LambeDepartment of Chemistry and Biochemistry, University of Arkansas, AR, USA.
Stef De LombaerdeLaboratory of Radiopharmacy, Ghent University, Ghent, Belgium.
Sarah PironLaboratory of Radiopharmacy, Ghent University, Ghent, Belgium.
Sam DoncheGhent University Hospital, Department of Nuclear Medicine, Ghent, Belgium.
Benedicte DescampsIBiTech-MEDISIP Ghent University, Department of Electronics and Information Systems, Ghent, Belgium.
Ingeborg GoethalsGhent University Hospital, Department of Nuclear Medicine, Ghent, Belgium.
Christian VanhoveIBiTech-MEDISIP Ghent University, Department of Electronics and Information Systems, Ghent, Belgium.
Filip De VosLaboratory of Radiopharmacy, Ghent University, Ghent, Belgium.
M Hassan BeyzaviDepartment of Chemistry and Biochemistry, University of Arkansas, AR, USA. Electronic address: beyzavi@uark.edu.
Ghent University Hospital · BEUniversity of Arkansas at Fayetteville · USGhent University · BE

Funding

Late-stage [18F]Fluorination: A Tandem Approach for the Synthesis of Positron Emission Tomography (PET) Radiotracers using Metal-Organic Frameworks (MOFs)R15GM132906 · NIGMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI BEYZAVI, HUDSON · 2019 to 2019
$428k
NIGMS NIH HHS R15 GM132906
6 · The paper itself

Abstract

introductionGlucose has been deemed the driving force of tumor growth for decades. However, research has shown that several tumors metabolically shift towards glutaminolysis. The development of radiolabeled glutamine derivatives could be a useful molecular imaging tool for visualizing these tumors. We elaborated on the glutamine-derived PET tracers by developing two novel probes, namely [ MATERIALS AND

methodsBoth tracers were labelled with fluorine-18 using our recently reported ruthenium-based direct aromatic fluorination method. Their affinity was evaluated with a [

resultsThe radiosynthesis of both tracers was successful with overall non-decay corrected yields of 18.46 ± 4.18% (n = 10) ([

conclusionWe investigated the imaging potential of two novel PET radiotracers [

Indexed as

Positron-Emission TomographyAnimalsCell Transformation, NeoplasticFluorine RadioisotopesGlutamineHumansModels, MolecularMolecular ConformationPC-3 CellsRadioactive TracersRadiochemistryRatsTissue DistributionFluorine-18Fluorine RadioisotopesGlutamineRadioactive Tracers[(18)F]fluoride[(18)F]fluorobiphenylglutamine[(18)F]fluorophenylglutamineGlutamineOncologyPositron emission tomographyRuthenium chemistry

Identifiers

PMID32447069
PMCPMC7814958
OpenAlexW3014840903

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.