Evidence map›Paper›PMID 32447050›Full record

ArticleBrain and language2020

Effects of age and left hemisphere lesions on audiovisual integration of speech.

Kelly Michaelis, Laura C Erickson, Mackenzie E Fama, Laura M Skipper-Kallal, Shihui Xing, Elizabeth H Lacey, Zainab Anbari, Gina Norato, Josef P Rauschecker, Peter E Turkeltaub

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and language, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Benefit of visual speech information for word comprehension in post-stroke aphasia.Cortex; a journal devoted to the study of the nervous system and behavior · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Kelly MichaelisNeurology Department and Center for Brain Plasticity and Recovery, Georgetown University Medical Center, Washington DC, USA.
Laura C EricksonNeurology Department and Center for Brain Plasticity and Recovery, Georgetown University Medical Center, Washington DC, USA; Neuroscience Department, Georgetown University Medical Center, Washington DC, USA.
Mackenzie E FamaNeurology Department and Center for Brain Plasticity and Recovery, Georgetown University Medical Center, Washington DC, USA; Department of Speech-Language Pathology & Audiology, Towson University, Towson, MD, USA.
Laura M Skipper-KallalNeurology Department and Center for Brain Plasticity and Recovery, Georgetown University Medical Center, Washington DC, USA.
Shihui XingNeurology Department and Center for Brain Plasticity and Recovery, Georgetown University Medical Center, Washington DC, USA; Department of Neurology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Elizabeth H LaceyNeurology Department and Center for Brain Plasticity and Recovery, Georgetown University Medical Center, Washington DC, USA; Research Division, MedStar National Rehabilitation Hospital, Washington DC, USA.
Zainab AnbariNeurology Department and Center for Brain Plasticity and Recovery, Georgetown University Medical Center, Washington DC, USA.
Gina NoratoClinical Trials Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Josef P RauscheckerNeuroscience Department, Georgetown University Medical Center, Washington DC, USA.
Peter E TurkeltaubNeurology Department and Center for Brain Plasticity and Recovery, Georgetown University Medical Center, Washington DC, USA; Research Division, MedStar National Rehabilitation Hospital, Washington DC, USA. Electronic address: turkeltp@georgetown.edu.
Georgetown University · USMedStar National Rehabilitation Hospital · USNational Institutes of Health · USSun Yat-sen University · CN

Funding

Sensory-motor integration in the auditory dorsal streamR01DC014989 · NIDCD · GEORGETOWN UNIVERSITY · PI RAUSCHECKER, JOSEF P · 2016 to 2025
$4.7M
Contributions of spared brain structures and connections to aphasia recoveryR01DC014960 · NIDCD · GEORGETOWN UNIVERSITY · PI TURKELTAUB, PETER ETHAN · 2017 to 2021
$4.0M
Sensory cortical organization and cross-modal plasticity in blind subjectsR01EY018923 · NEI · GEORGETOWN UNIVERSITY · PI RAUSCHECKER, JOSEF P · 2009 to 2016
$2.4M
Georgetown-Howard Universities Center for Clinical and Translational Science (GHUKL2TR000102 · NCATS · GEORGETOWN UNIVERSITY · PI MELLMAN, THOMAS A, VERBALIS, JOSEPH G · 2012 to 2014
$1.7M
Processing Streams in the Cerebral CortexR56NS052494 · NINDS · GEORGETOWN UNIVERSITY · PI RAUSCHECKER, JOSEF P · 2013 to 2013
$511k
NCATS NIH HHS KL2 TR000102NEI NIH HHS R01 EY018923NIDCD NIH HHS R01 DC014960NIDCD NIH HHS R01 DC014989NINDS NIH HHS R56 NS052494
6 · The paper itself

Abstract

Neuroimaging studies have implicated left temporal lobe regions in audiovisual integration of speech and inferior parietal regions in temporal binding of incoming signals. However, it remains unclear which regions are necessary for audiovisual integration, especially when the auditory and visual signals are offset in time. Aging also influences integration, but the nature of this influence is unresolved. We used a McGurk task to test audiovisual integration and sensitivity to the timing of audiovisual signals in two older adult groups: left hemisphere stroke survivors and controls. We observed a positive relationship between age and audiovisual speech integration in both groups, and an interaction indicating that lesions reduce sensitivity to timing offsets between signals. Lesion-symptom mapping demonstrated that damage to the left supramarginal gyrus and planum temporale reduces temporal acuity in audiovisual speech perception. This suggests that a process mediated by these structures identifies asynchronous audiovisual signals that should not be integrated.

Indexed as

Acoustic StimulationAgedAgingAuditory PerceptionFemaleFunctional LateralityHumansMaleMiddle AgedPhotic StimulationSpeech PerceptionVisual PerceptionAudiovisual integrationLesion symptom mappingMcGurk effectPlanum temporaleSupramarginal gyrus

Identifiers

PMID32447050
PMCPMC7379161
OpenAlexW3028070549

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.