Evidence map›Paper›PMID 32447015›Full record

ArticleNeuroImage2020

Morphology of perivascular spaces and enclosed blood vessels in young to middle-aged healthy adults at 7T: Dependences on age, brain region, and breathing gas.

Xiaopeng Zong, Chunfeng Lian, Jordan Jimenez, Koji Yamashita, Dinggang Shen, Weili Lin

Open access · goldAbstract read
In one paragraph

Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xiaopeng ZongBiomedical Research Imaging Center, Chapel Hill, NC, USA; Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: xiaopeng_zong@med.unc.edu.
Chunfeng LianBiomedical Research Imaging Center, Chapel Hill, NC, USA; Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jordan JimenezBiomedical Research Imaging Center, Chapel Hill, NC, USA.
Koji YamashitaBiomedical Research Imaging Center, Chapel Hill, NC, USA; Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Dinggang ShenBiomedical Research Imaging Center, Chapel Hill, NC, USA; Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Weili LinBiomedical Research Imaging Center, Chapel Hill, NC, USA; Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Imaging Center · USUniversity of North Carolina at Chapel Hill · US

Funding

Calcium Signalling Among Non-Neuronal Brain CellsR01NS041031 · NINDS · NEW YORK MEDICAL COLLEGE · PI NEDERGAARD, MAIKEN · 2001 to 2004
$1.3M
Characterizing morphological and hemodynamic characteristics of human brain perivascular spaces with aging using 7T MRIR21NS095027 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIN, WEILI · 2016 to 2017
$418k
NINDS NIH HHS R01 NS041031NINDS NIH HHS R21 NS095027
6 · The paper itself

Abstract

Perivascular spaces (PVSs) are fluid-filled spaces surrounding penetrating blood vessels in the brain and are an integral pathway of the glymphatic system. A PVS and the enclosed blood vessel are commonly visualized as a single vessel-like complex (denoted as PVSV) in high-resolution MRI images. Quantitative characterization of the PVSV morphology in MRI images in healthy subjects may serve as a reference for detecting disease related PVS and/or blood vessel alterations in patients with brain diseases. To this end, we evaluated the age dependences, spatial heterogeneities, and dynamic properties of PVSV morphological features in 45 healthy subjects (21-55 years old), using an ultra-high-resolution three-dimensional transverse relaxation time weighted MRI sequence (0.41 ​× ​0.41 ​× ​0.4 ​mm

Indexed as

AdultAgingBlood VesselsFemaleGlymphatic SystemHealthy VolunteersHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedYoung AdultAgingCarbogen breathingGlymphatic systemHeterogeneityHigh field MRIHuman brainMorphologyPerivascular spaces

Identifiers

PMID32447015
PMCPMC7485170
OpenAlexW3026922848

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.