ArticleNeurobiology of aging2020
Association of sleep with cognition and beta amyloid accumulation in adults with Down syndrome.
Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Pharmacological Approaches to the Treatment of Dementia in Down Syndrome: A Systematic Review of Randomized Clinical Studies.Molecules (Basel, Switzerland) · 2022Pooled it
- Evaluating Scoring Mechanisms for Measuring the Stroop Effect in Individuals With Down Syndrome.Journal of intellectual disability research : JIDR · 2026Review
- Development and validation of a Cog-Free risk predicting tool for dementia in a community setting.General psychiatry · 2026Article
- Circadian Rest-Activity Rhythms, Cognition, and Alzheimer Disease Dementia in Adults With Down Syndrome.Neurology · 2026Article
- Impact of Alzheimer's disease on sleep in adults with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Resistance and resilience to Alzheimer's disease in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Preliminary investigation of obstructive sleep apnea and Alzheimer's disease in down syndrome.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Physical Activity and Cognitive Impairment in a Group of Adults with Down Syndrome from North-Eastern Romania.Journal of clinical medicine · 2024Article
- Cerebrovascular disease emerges with age and Alzheimer's disease in adults with Down syndrome.Scientific reports · 2024Article
- Age of Alzheimer's disease diagnosis in people with Down syndrome and associated factors: Results from the Horizon 21 European Down syndrome consortium.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Insomnia Symptoms Are Associated with Measures of Functional Deterioration and Dementia Status in Adults with Down Syndrome at High Risk for Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Article
- Psychometric properties of inhibitory control measures among youth with Down syndrome.Journal of intellectual disability research : JIDR · 2023Article
- Executive functioning and verbal fluency performance in youth with Down syndrome.Research in developmental disabilities · 2022Article
- Physical Activity and Physical and Mental Health in Middle-Aged Adults with Down Syndrome.Journal of policy and practice in intellectual disabilities · 2022Article
- Review
- Impact of the COVID-19 pandemic on daily life, mood, and behavior of adults with Down syndrome.Disability and health journal · 2022Article
- Cognitive outcome measures for tracking Alzheimer's disease in Down syndrome.International review of research in developmental disabilities · 2022Article
- Obstructive sleep apnea, cerebrovascular disease, and amyloid in older adults with Down syndrome across the Alzheimer's continuum.Sleep advances : a journal of the Sleep Research Society · 2022Article
- Exploring the role of sex differences in Alzheimer's disease pathogenesis in Down syndrome.Frontiers in neuroscience · 2022Review
- Alzheimer's disease associated with Down syndrome: a genetic form of dementia.The Lancet. Neurology · 2021Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Adults with Down syndrome have an increased risk for both disordered sleep and Alzheimer's disease (AD). In the general population, disrupted sleep has been linked to beta amyloid accumulation, an early pathophysiologic feature of AD. In this study, the association among sleep, beta amyloid, and measures of AD-related cognitive decline was examined in 47 non-demented adults with Down syndrome (aged 26-56 years). Sleep was measured using actigraphy over 7 nights. Pittsburgh Compound B positron emission tomography was used to assess global and striatal beta amyloid burden. Participants had the following clinical AD status: 7 (15%) mild cognitive impairment and 40 (85%) cognitively unaffected. Average length of night-time awakenings was significantly positively associated with striatal beta amyloid and decreased cognitive performance in executive functioning and motor planning and coordination. Findings suggest that disrupted sleep is associated with beta amyloid accumulation and cognitive features of preclinical AD in Down syndrome. Early identification and treatment of sleep problems could be a lifestyle intervention that may delay beta amyloid accumulation and cognitive decline in this AD vulnerable group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.