Evidence map›Paper›PMID 32446738›Full record

ArticleAmerican journal of ophthalmology2020

Baseline Visual Field Findings in the RUSH2A Study: Associated Factors and Correlation With Other Measures of Disease Severity.

Jacque L Duncan, Wendi Liang, Maureen G Maguire, Isabelle Audo, Allison R Ayala, David G Birch, Joseph Carroll, Janet K Cheetham, Simona Degli Esposti, Todd A Durham and 12 more

Erratum issuedOpen access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 41 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. From Sound to Stability: Lessons Learned From the CRUSH Study on Hearing Loss Progression and Vestibular Phenotype in Usher Syndrome Type 2A.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2026
    Observational
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Observational
  14. Functional Vision in Patients With Biallelic USH2A Variants.American journal of ophthalmology · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Observational
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 13 institutions in 4 countries.

Jacque L DuncanUniversity of California, San Francisco, San Francisco, CA, USA.
Wendi LiangJaeb Center for Health Research, Tampa, FL, USA.
Maureen G MaguireUniversity of Pennsylvania, Philadelphia, PA, USA.
Isabelle AudoInstitut de la Vision, Sorbonne Université, INSERM, CNRS, Paris, France; Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM-DGOS CIC1423, Paris, France.
Allison R AyalaJaeb Center for Health Research, Tampa, FL, USA. Electronic address: ffbcorrespauth@jaeb.org.
David G BirchRetina Foundation of the Southwest, Dallas, TX, USA.
Joseph CarrollMedical College of Wisconsin Eye Institute, Milwaukee, WI, USA.
Janet K CheethamFoundation Fighting Blindness, Columbia, MD, USA.
Simona Degli EspostiMoorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom.
Todd A DurhamFoundation Fighting Blindness, Columbia, MD, USA.
Laura ErkerCasey Eye Institute-Oregon Health & Science University, Portland, OR, USA.
Sina FarsiuDepartment of Ophthalmology, Duke University, Durham, NC, USA.
Frederick L FerrisOphthalmic Research Consultants, Waxhaw, NC, USA.
Elise HeonDepartments of Ophthalmology and Vision Sciences, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada.
Robert B HufnagelNational Eye Institute, Bethesda, MD, USA.
Alessandro IannacconeDepartment of Ophthalmology, Duke University, Durham, NC, USA.
Glenn J JaffeDepartment of Ophthalmology, Duke University, Durham, NC, USA.
Christine N KayVitreoretinal Associates, Gainesville, FL, USA.
Michel MichaelidesMoorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom.
Mark E PennesiCasey Eye Institute-Oregon Health & Science University, Portland, OR, USA.
José-Alain SahelInstitut de la Vision, Sorbonne Université, INSERM, CNRS, Paris, France; Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM-DGOS CIC1423, Paris, France; Department of Ophthalmology, The University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Foundation Fighting Blindness Consortium Investigator Group
Duke University · USCentre National de la Recherche Scientifique · FRFoundation Fighting Blindness · USJaeb Center for Health Research · USMoorfields Eye Hospital · GBOregon Health & Science University · USMedical College of Wisconsin · USNational Eye Institute · USRetina Foundation of the Southwest · USRetina Vitreous Associates of Florida · USUniversity of California, San Francisco · USUniversity of Pennsylvania · USUniversity of Toronto · CA

Funding

Clinical ophthalmic molecular diagnostics and discoveryZIAEY000564 · NEI · NATIONAL EYE INSTITUTE · PI GUAN, BIN · 2019 to 2025
$7.9M
Foundation Fighting Blindness RUSH2A - CONSORTIUM - 2016Intramural NIH HHS Z99 EY999999Intramural NIH HHS ZIA EY000564
6 · The paper itself

Abstract

purposeTo report baseline visual fields in the Rate of Progression in USH2A-related Retinal Degeneration (RUSH2A) study.

designCross-sectional study within a natural history study.

methodsSetting: multicenter, international. STUDY POPULATION: Usher syndrome type 2 (USH2) (n = 80) or autosomal recessive nonsyndromic retinitis pigmentosa (ARRP) (n = 47) associated with biallelic disease-causing sequence variants in USH2A. OBSERVATION PROCEDURES: Repeatability of full-field static perimetry (SP) and between-eye symmetry of kinetic perimetry (KP) were evaluated with intraclass correlation coefficients (ICCs). The association of demographic and clinical characteristics with total hill of vision (V

main outcome measuresV

resultsUSH2 participants had more severe visual field loss than ARRP participants (P < .001, adjusting for disease duration, age of enrollment). Mean V

conclusionsUSH2 participants had more visual field loss than participants with USH2A-related ARRP, adjusting for duration of disease and age of enrollment. V

Indexed as

AdultCross-Sectional StudiesDisease ProgressionElectroretinographyExtracellular Matrix ProteinsFemaleHumansLongitudinal StudiesMaleMiddle AgedResearch DesignRetinaRetinitis PigmentosaSeverity of Illness IndexUsher SyndromesVision DisordersExtracellular Matrix ProteinsUSH2A protein, human

Identifiers

PMID32446738
PMCPMC8596302
OpenAlexW3027994700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.